Julia Bohannon

TLR agonists as mediators of trained immunity: mechanistic insight and immunotherapeutic potential to combat infection. AM Owen, JB Fults, NK Patil, A Hernandez, JK Bohannon Frontiers in Immunology, 3866, 2021.

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Immune checkpoints: novel therapeutic targets to attenuate sepsis-induced immunosuppression. MA McBride, TK Patil, JK Bohannon, A Hernandez, ER Sherwood, ... Frontiers in immunology, 3726, 2021.

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-Glucan Induces Distinct and Protective Innate Immune Memory in Differentiated Macrophages. CL Stothers, KR Burelbach, AM Owen, NK Patil, MA McBride, ... The Journal of Immunology 207 (11), 2785-2798, 2021.

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What's New in Shock, April 2021?. JK Bohannon, ER Sherwood Shock 55 (4), 419-422, 2021.

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A Murine Model of Full-Thickness Scald Burn Injury with Subsequent Wound and Systemic Bacterial Infection. A Hernandez, NK Patil, JK Bohannon Sepsis, 111-120, 2021.

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The metabolic basis of immune dysfunction following sepsis and trauma. MA McBride, AM Owen, CL Stothers, A Hernandez, L Luan, KR Burelbach, ... Frontiers in immunology 11, 1043, 2020.

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Monophosphoryl lipid A attenuates multiorgan dysfunction during post-burn pseudomonas aeruginosa pneumonia in sheep. S Fukuda, K Ihara, JK Bohannon, A Hernandez, NK Patil, L Luan, ... Shock (Augusta, Ga.) 53 (3), 307, 2020.

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BETA-GLUCAN AUGMENTS MACROPHAGE ANTIMICROBIAL ACTIVITY AND METABOLISM. KR Burelbach, C Stothers, L Luan, JK Bohannon, DL Williams, ... SHOCK 53, 117-117, 2020.

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ROLE OF INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE-M IN MURINE MODELS OF LPS INDUCED INFLAMMATION AND BACTERIAL INFECTION. L Luan, NK Patil, A Hernandez, C Stothers, AM Owen, KR Burelbach, ... SHOCK 53, 118-118, 2020.

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MPLA AUGMENTS PROTECTION FROM INFECTION BY INDUCING MITOCHONDRIAL BIOGENESIS AND ITACONATE PRODUCTION. MA McBride, L Luan, JK Bohannon, C Stothers, A Hernandez, ... SHOCK 53, 48-49, 2020.

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PRECLINICAL EVALUATION OF A NOVEL SYNTHETIC TOLL-LIKE RECEPTOR 4 AGONIST TO ENHANCE RESISTANCE TO ISCHEMIA REPERFUSION-INDUCED ACUTE KIDNEY INJURY. A Hernandez, LN Scarfe, RD Delgado, NK Patil, L Himmel, JK Bohannon, ... SHOCK 53, 91-92, 2020.

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ASSESSING THE FUNCTION OF DECTIN-1 AND TOLL-LIKE RECEPTOR 2 IN BETA-GLUCAN-MEDIATED PROTECTION AGAINST PSEUDOMONAS AERUGINOSA INFECTION. C Stothers, KR Burelbach, L Luan, JK Bohannon, NK Patil, A Hernandez, ... SHOCK 53, 120-121, 2020.

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MYD88-SPECIFIC TLR AGONISTS MEDIATE PROTECTION AGAINST NOSOCOMIAL INFECTIONS THROUGH MACROPHAGE REPROGRAMMING. AM Owen, L Luan, BA Fensterheim, A Hernandez, C Stothers, JB Fults, ... SHOCK 53, 18-18, 2020.

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Phosphorylated hexaacyl disaccharides (phads) for treating or preventing infections. E Sherwood, A Hernandez, J Bohannon US Patent App. 16/610,125, 2020.

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Immunobiology and application of toll-like receptor 4 agonists to augment host resistance to infection. A Hernandez, NK Patil, CL Stothers, L Luan, MA McBride, AM Owen, ... Pharmacological research 150, 104502, 2019.

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Regulation of leukocyte function by citric acid cycle intermediates. NK Patil, JK Bohannon, A Hernandez, TK Patil, ER Sherwood Journal of leukocyte biology 106 (1), 105-117, 2019.

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Phosphorylated hexaacyl disaccharides augment host resistance against common nosocomial pathogens. A Hernandez, L Luan, CL Stothers, NK Patil, JB Fults, BA Fensterheim, ... Critical care medicine 47 (11), e930, 2019.

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Metabolism drives monocytes during inflammation: What we do and do not know. NK Patil, JK Bohannon, ER Sherwood Journal of leukocyte biology 105 (2), 211-213, 2019.

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NOVEL SYNTHETIC TOLL-LIKE RECEPTOR 4 AGONISTS ENHANCE RESISTANCE TO INFECTION WITH COMMON BACTERIAL PATHOGENS. A Hernandez, L Luan, CL Stothers, JB Fults, BA Fensterheim, NK Patil, ... SHOCK 51 (6), 31-32, 2019.

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BETA-GLUCAN PROTECTS MICE FROM LETHAL PSEUDOMONAS AERUGINOSA INFECTION: INSIGHTS INTO THE SIGNALING MECHANISMS SUPPORTING TRAINED IMMUNITY. CL Stothers, L Luan, JK Bohannon, K Burelbach, N Kinnare, DL Williams, ... SHOCK 51 (6), 86-87, 2019.

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IMMUNORESPONSIVE GENE 1 AND ITACONATE: KEY MEDIATORS OF TLR4 AGONIST-INDUCED PROTECTION AGAINST INFECTION. NK Patil, L Luan, JK Bohannon, A Hernandez, B Fensterheim, ... SHOCK 51 (6), 43-43, 2019.

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MITOCHONDRIAL BIOGENESIS PLAYS AN IMPORTANT ROLE IN MONOPHOSPHORYL LIPID A-MEDIATED REPROGRAMMING OF MACROPHAGE METABOLISM AND FUNCTION. NK Patil, B Fensterheim, L Luan, JK Bohannon, A Hernandez, ... SHOCK 51 (6), 57-58, 2019.

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The biology of natural killer cells during sepsis. Y Guo, NK Patil, L Luan, JK Bohannon, ER Sherwood Immunology 153 (2), 190-202, 2018.

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The TLR4 agonist monophosphoryl lipid A drives broad resistance to infection via dynamic reprogramming of macrophage metabolism. BA Fensterheim, JD Young, L Luan, RR Kleinbard, CL Stothers, NK Patil, ... The Journal of Immunology 200 (11), 3777-3789, 2018.

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Frontline Science: Anti PD L1 protects against infection with common bacterial pathogens after burn injury. NK Patil, L Luan, JK Bohannon, A Hernandez, Y Guo, ER Sherwood Journal of leukocyte biology 103 (1), 23-33, 2018.

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Hypoxia-inducible factor-1 regulation of myeloid cells. CL Stothers, L Luan, BA Fensterheim, JK Bohannon Journal of Molecular Medicine 96 (12), 1293-1306, 2018.

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SHOCK 2018 7 . JK Bohannon, ER Sherwood 2 (4), 244-246,249, 2018.

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What's New in Shock, July 2018?. JK Bohannon, ER Sherwood Shock 50 (1), 1-4, 2018.

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THE TLR4 AGONIST MONOPHOSPHORYL LIPID A INDUCES DYNAMIC REPROGRAMMING OF MACROPHAGE METABOLISM FOR ENHANCEMENT OF ANTIMICROBIAL FUNCTIONS AND INFECTION RESISTANCE. JK Bohannon, BA Fensterheim, JD Young, I Trenary, L Luan, ... SHOCK 49 (6), 93-93, 2018.

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DECTIN-1 AND TOLL-LIKE RECEPTOR 2 ARE NOT ESSENTIAL FOR BETA-GLUCAN-INDUCED PROTECTION FROM PSEUDOMONAS AERUGINOSA INFECTION. CL Stothers, LM Luan, JK Bohannon, A Hernandez, BA Fensterheim, ... SHOCK 49 (6), 123-124, 2018.

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THE TLR4 AGONIST MONOPHOSPHORYL LIPID A MEDIATES BROAD PROTECTION AGAINST INFECTION VIA AUGMENTATION OF INNATE ANTIMICROBIAL CELL FUNCTIONS. L Luan, BA Fensterheim, C Stothers, JB Fults, Y Guo, NK Patil, ... SHOCK 49 (6), 19-19, 2018.

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SYNTHETIC PHOSPHORYLATED HEXAACYL DISACCHARIDES ARE POTENT TLR4 AGONISTS AND AUGMENT HOST RESISTANCE AGAINST COMMON NOSOCOMIAL PATHOGENS. A Hernandez, JK Bohannon, L Luan, JB Fults, BA Fensterheim, ... SHOCK 49 (6), 30-30, 2018.

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TREATMENT WITH TLR AGONISTS PROTECT AGAINST SEVERE NOSOCOMIAL INFECTIONS. JK Bohannon, BA Fensterheim, L Luan, JB Fults, A Hernandez, NK Patil, ... SHOCK 49 (6), 93-94, 2018.

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ANTI-PD-L1 ATTENUATES T CELL DYSFUNCTION AND PROTECTS AGAINST INFECTION WITH COMMON NOSOCOMIAL PATHOGENS AFTER SEVERE BURN INJURY. N Patil, L Luan, JK Bohannon, A Hernandez, Y Guo, ER Sherwood SHOCK 49 (6), 12-13, 2018.

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ENDOTHELIAL MTOR SIGNALING DRIVES VASCULAR INFLAMMATION. CL Stothers, Y Guo, K Travisano, LM Luan, JK Bohannon, M Montano, ... SHOCK 49 (6), 81-82, 2018.

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IL-15 enables septic shock by maintaining NK cell integrity and function. Y Guo, L Luan, NK Patil, J Wang, JK Bohannon, W Rabacal, ... The Journal of Immunology 198 (3), 1320-1333, 2017.

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The cytokine response to lipopolysaccharide does not predict the host response to infection. BA Fensterheim, Y Guo, ER Sherwood, JK Bohannon The Journal of Immunology 198 (8), 3264-3273, 2017.

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Flt3 ligand treatment attenuates T cell dysfunction and improves survival in a murine model of burn wound sepsis. NK Patil, JK Bohannon, L Luan, Y Guo, BFA Hernandez, J Wang, ... Shock (Augusta, Ga.) 47 (1), 40, 2017.

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Comparative transcriptome profiles of human blood in response to the toll-like receptor 4 ligands lipopolysaccharide and monophosphoryl lipid A. L Luan, NK Patil, Y Guo, A Hernandez, JK Bohannon, BA Fensterheim, ... Scientific reports 7 (1), 1-16, 2017.

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Quantification of regional aerosol deposition patterns as a function of aerodynamic particle size in rhesus macaques using PET/CT imaging. PA Dabisch, Z Xu, JA Boydston, J Solomon, JK Bohannon, JJ Yeager, ... Inhalation toxicology 29 (11), 506-515, 2017.

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Fms-like tyrosine kinase-3 ligand increases resistance to burn wound infection through effects on plasmacytoid dendritic cells. L Bae, JK Bohannon, W Cui, M Vinish, T Toliver-Kinsky BMC immunology 18 (1), 1-9, 2017.

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Abstract P20: severe injury leads to plasmin consumption below a critical threshold required to heal soft tissue injury. E Amaro, NA Mignemi, SN Moore-Lotridge, BHY Gibson, CE Baker, ... Plastic and Reconstructive Surgery-Global Open 5 (4S), 115-116, 2017.

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THE LPS-ELICITED CYTOKINE RESPONSE DOES NOT PREDICT THE HOST RESPONSE TO INFECTION. BA Fensterheim, Y Guo, ER Sherwood, JK Bohannon SHOCK 47 (6), 80-81, 2017.

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CHARACTERIZATION OF LYMPHOCYTE METABOLISM IN A MURINE SEPSIS MODEL. R Parker, JK Bohannon, BA Fensterheim, N Patil, L Luan, Y Guo, ... SHOCK 47 (6), 137-137, 2017.

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BURN WOUND SEPSIS INDUCED T CELL DYSFUNCTION: ANTI-PD-L1 ANTIBODY IMPROVES SURVIVAL. NK Patil, L Luan, JK Bohannon, A Hernandez, Y Guo, ER Sherwood SHOCK 47 (6), 67-68, 2017.

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TREATMENT WITH THE TLR4 AGONIST MONOPHOSPHORYL LIPID A PROTECTS MICE AGAINST SEVERE STAPHYLOCOCCUS AUREUS INFECTION VIA AUGMENTATION OF INNATE ANTIMICROBIAL CELL FUNCTIONS. JK Bohannon, BA Fensterheim, L Luan, A Hernandez, Y Guo, NK Patil, ... SHOCK 47 (6), 27-28, 2017.

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ENHANCEMENT OF INNATE ANTI-MICROBIAL IMMUNITY USING NOVEL SYNTHETIC TLR4 AGONISTS. A Hernandez, JK Bohannon, L Luan, BA Fensterheim, JB Fults, NK Patil, ... SHOCK 47 (6), 124-124, 2017.

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Immunotherapy: a promising approach to reverse sepsis-induced immunosuppression. NK Patil, JK Bohannon, ER Sherwood Pharmacological research 111, 688-702, 2016.

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Role of G CSF in monophosphoryl lipid A mediated augmentation of neutrophil functions after burn injury. JK Bohannon, L Luan, A Hernandez, A Afzal, Y Guo, NK Patil, ... Journal of leukocyte biology 99 (4), 629-640, 2016.

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The role of MyD88 and TRIF dependent signaling in monophosphoryl lipid A induced expansion and recruitment of innate immunocytes. A Hernandez, JK Bohannon, L Luan, BA Fensterheim, Y Guo, NK Patil, ... Journal of leukocyte biology 100 (6), 1311-1322, 2016.

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IL-15 Superagonist Expands mCD8+ T, NK and NKT Cells after Burn Injury but Fails to Improve Outcome during Burn Wound Infection. NK Patil, L Luan, JK Bohannon, Y Guo, A Hernandez, B Fensterheim, ... PloS one 11 (2), e0148452, 2016.

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Preclinical evaluation of Flt3 ligand to improve T cell adaptive immune response during sepsis. NK Patil, JK Bohannon, L Luan, Y Guo, ER Sherwood The FASEB Journal 30, 1202.3-1202.3, 2016.

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Treatment with TLR4 agonists protect against infection after severe burn injury. JK Bohannon, L Luan, A Hernandez, BA Fensterheim, N Patil, Y Guo, ... The Journal of Immunology 196 (1 Supplement), 200.17-200.17, 2016.

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Feeling the burn: sphingolipids and infection risk after thermal injury. JK Bohannon, ER Sherwood Crit. Care 13, R183, 2016.

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FLT3 LIGAND ATTENUATES ADAPTIVE IMMUNE SYSTEM DYSFUNCTION DURING BURN WOUND SEPSIS. NK Patil, JK Bohannon, L Luan, Y Guo, E Sherwood SHOCK 45 (6), 21-21, 2016.

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THE ROLE OF MYD88-AND TRIF-DEPENDENT SIGNALING IN THE TRAFFICKING OF INNATE IMMUNE CELLS BY MONOPHOSPHORYL LIPID A. A Hernandez, L Luan, JK Bohannon, BA Fensterheim, Y Guo, NK Patil, ... SHOCK 45 (6), 94-94, 2016.

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VERY LATE TLR4-DRIVEN ELEVATION IN MACROPHAGE OXIDATIVE METABOLISM FOLLOWING EARLY AEROBIC GLYCOLYSIS PROMOTES INFECTION RESOLUTION. BA Fensterheim, JK Bohannon, Y Guo, E Sherwood SHOCK 45 (6), 62-62, 2016.

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INTERLEUKIN (IL)-15 PLAYS A CRITICAL ROLE IN THE PATHOGENESIS OF CLP-AND LPS-INDUCED SEPTIC SHOCK BY MAINTAINING NK AND MEMORY CD8 (+) T CELLS. Y Guo, L Luan, NK Patil, JK Bohannon, J Wang, BA Fensterheim, ... SHOCK 45 (6), 16-16, 2016.

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TREATMENT WITH TLR AGONISTS PROTECT AGAINST INFECTION AFTER SEVERE BURN INJURY. JK Bohannon, L Luan, A Hernandez, BA Fensterheim, Y Guo, ... SHOCK 45 (6), 110-111, 2016.

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MyD88-associated Toll-like receptor ligands prime macrophage metabolism for infection. B Fensterheim, J Bohannon, Y Guo, E Sherwood The Journal of Immunology 196 (1 Supplement), 203.24-203.24, 2016.

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Interleukin (IL)-15 superagonist mediates immunotoxicity by inducing hyperproliferation of activated NK cells and production of IFN . Y Guo, L Luan, W Rabacal, J Bohannon, B Fensterheim, A Hernandez, ... The Journal of Immunology 196 (1 Supplement), 142.23-142.23, 2016.

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The lack of NK and mCD8+ T cells in IL-15KO mice confers resistance to septic shock. Y Guo, L Luan, J Bohannon, N Patil, B Fensterheim, A Hernandez, ... The Journal of Immunology 196 (1 Supplement), 60.9-60.9, 2016.

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IL-15 superagonist-mediated immunotoxicity: role of NK cells and IFN- . Y Guo, L Luan, W Rabacal, JK Bohannon, BA Fensterheim, A Hernandez, ... The Journal of Immunology 195 (5), 2353-2364, 2015.

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IL-15 Superagonist. ER Sherwood, BAF Bohannon, A Hernandez, Y Guo, L Luan, ... .

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TREATMENT WITH A TLR4 AGONIST ENHANCES NEUTROPHIL RESPONSES TO INFECTION AFTER BURN. J Bohannon, L Luan, A Hernandez, E Sherwood SHOCK 43 (6), 37-37, 2015.

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MOLECULAR MECHANISMS OF MONOPHOSPHORYL LIPID A INDUCED NEUTROPHIL MOBILIZATION AND RECRUITMENT. A Hernandez, L Luan, J Bohannon, B Fensterheim, E Sherwood SHOCK 43 (6), 30-31, 2015.

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INTERLEUKIN (IL)-15 FACILITATES THE PATHOGENESIS OF CLP-INDUCED SEPTIC SHOCK BY ACTIVATION OF NK, NKT AND MEMORY CD8 (+) T LYMPHOCYTES. Y Guo, L Luan, NK Patil, J Bohannon, E Sherwood SHOCK 43 (6), 18-18, 2015.

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BURN WOUND INFECTION CAUSES SIGNIFICANT ADAPTIVE IMMUNE SYSTEM DYSFUNCTION. NK Patil, J Bohannon, L Luan, Y Guo, E Sherwood SHOCK 43 (6), 99-99, 2015.

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INTERLEUKIN-15 TREATMENT EXPANDS SPLENIC NK AND CD8 T CELLS BUT FAILS TO IMPROVE SURVIVAL DURING BURN WOUND SEPSIS. NK Patil, L Luan, Y Guo, J Bohannon, E Sherwood SHOCK 43 (6), 39-39, 2015.

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The role of CXCL10 in the pathogenesis of experimental septic shock. DS Herzig, L Luan, JK Bohannon, TE Toliver-Kinsky, Y Guo, ... Critical care 18 (3), 1-18, 2014.

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MPLA ENHANCES NEUTROPHIL RESPONSES TO INFECTION AFTER BURN. J Bohannon, A Hernandez, L Luan, E Sherwood SHOCK 41, 12-12, 2014.

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THE ROLE OF CXCL10 IN THE PATHOGENESIS OF EXPERIMENTAL SEPTIC SHOCK. L Luan, DS Herzig, J Bohannon, T Toliver-Kinsky, Y Guo, E Sherwood SHOCK 41, 27-28, 2014.

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The immunobiology of TLR4 agonists: from endotoxin tolerance to immunoadjuvants. JK Bohannon, A Hernandez, P Enkhbaatar, WL Adams, ER Sherwood Shock (Augusta, Ga.) 40 (6), 451, 2013.

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EFFECT OF MPLA ON IMMUNE RESPONSES TO A BURN WOUND INFECTION. J Bohannon, E Sherwood SHOCK 39, 21-21, 2013.

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STAT1-deficient mice are resistant to CLP-induced septic shock. D Herzig, G Fang, TE Toliver-Kinsky, Y Guo, J Bohannon, ER Sherwood Shock (Augusta, Ga.) 38 (4), 395, 2012.

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The role of natural killer cells in the pathogenesis of sepsis: the ongoing enigma. J Bohannon, Y Guo, ER Sherwood Critical care 16 (6), 1-2, 2012.

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Dendritic cell modification of neutrophil responses to infection after burn injury. J Bohannon, W Cui, E Sherwood, T Toliver-Kinsky The Journal of Immunology 185 (5), 2847-2853, 2010.

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DENDRITIC CELL MODIFICATION OF NEUTROPHIL RESPONSES AFTER BURN INJURY. J Bohannon, W Cui, T Toliver-Kinsky SHOCK 33, 22-22, 2010.

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Fms-like tyrosine kinase-3 ligand alters antigen-specific responses to infections after severe burn injury. J Bohannon, G Fang, W Cui, E Sherwood, T Toliver-Kinsky Shock (Augusta, Ga.) 32 (4), 435, 2009.

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Endogenous Fms-like tyrosine kinase-3 ligand levels are not altered in mice after a severe burn and infection. JK Bohannon, W Cui, T Toliver-Kinsky BMC immunology 10 (1), 1-8, 2009.

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Prophylactic treatment with fms-like tyrosine kinase-3 ligand after burn injury enhances global immune responses to infection. J Bohannon, W Cui, R Cox, R Przkora, E Sherwood, T Toliver-Kinsky The Journal of Immunology 180 (5), 3038-3048, 2008.

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Endogenous Flt3-ligand levels are not altered in mice after a severe burn and infection. J Bohannon, W Cui, T Toliver-Kinsky Shock 27, 48-48, 2007.

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Application of MyD88-selective Toll-like Receptor (TLR) Agonist Protection in Nosocomial Infections. JB Fults, AM Owen, L Luan, BA Fensterheim, A Hernandez, CL Stothers, ... .

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