Linda Lieu

Lieu, L., Hinkle, J., Syka, J. & Fornelli, L. Leveraging ion-ion and ion-photon reactions to improve the sequencing of proteins carrying multiple disulfide bonds: the human serum albumin case study. ChemRxiv (2024) doi:https://doi.org/10.26434/chemrxiv-2024-fdzkf.

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Lieu, L. et al. Enhanced payload localization in antibody-drug conjugates using a middle-down mass spectrometry approach with proton transfer charge reduction. ChemRxiv (2024) doi:https://doi.org/10.26434/chemrxiv-2024-qm5lh.

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Kline, J. T., Mullen, C., Durbin, K. R., Oates, R. N., Huguet, R., Syka, J. E. P., & Fornelli, L. (2021). Sequential Ion-Ion Reactions for Enhanced Gas-Phase Sequencing of Large Intact Proteins in a Tribrid Orbitrap Mass Spectrometer. Journal of the American Society for Mass Spectrometry, 32(9), 2334-2345. https://doi.org/10.1021/jasms.1c00062

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Huguet, R., Mullen, C., Srzentic , K., Greer, J. B., Fellers, R. T., Zabrouskov, V., Syka, J. E. P., Kelleher, N. L., & Fornelli, L. (2019). Proton Transfer Charge Reduction Enables High-Throughput Top-Down Analysis of Large Proteoforms. Analytical Chemistry, 91(24), 15732-15739. https://doi.org/10.1021/acs.analchem.9b03925

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Toby, T. K., Fornelli, L., Srzentic , K., DeHart, C. J., Levitsky, J., Friedewald, J., & Kelleher, N. L. (2019). A comprehensive pipeline for translational top-down proteomics from a single blood draw. Nature Protocols, 14(1), 119-152. https://doi.org/10.1038/s41596-018-0085-7 van der Burgt, Y. E. M., Kilgour, D. P. A., Tsybin, Y. O., Srzentic , K., Fornelli, L., Beck, A., Wuhrer, M., & Nicolardi, S. (2019). Structural Analysis of Monoclonal Antibodies by Ultrahigh Resolution MALDI In-Source Decay FT-ICR Mass Spectrometry. Analytical Chemistry, 91(3), 2079-2085. https://doi.org/10.1021/acs.analchem.8b04515

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Fornelli, L., Srzentic , K., Huguet, R., Mullen, C., Sharma, S., Zabrouskov, V., Fellers, R. T., Durbin, K. R., Compton, P. D., & Kelleher, N. L. (2018). Accurate Sequence Analysis of a Monoclonal Antibody by Top-Down and Middle-Down Orbitrap Mass Spectrometry Applying Multiple Ion Activation Techniques. Analytical Chemistry, 90(14), 8421-8429. https://doi.org/10.1021/acs.analchem.8b00984

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Srzentic , K., Nagornov, K. O., Fornelli, L., Lobas, A. A., Ayoub, D., Kozhinov, A. N., Gasilova, N., Menin, L., Beck, A., Gorshkov, M. V., Aizikov, K., & Tsybin, Y. O. (2018). Multiplexed Middle-Down Mass Spectrometry as a Method for Revealing Light and Heavy Chain Connectivity in a Monoclonal Antibody. Analytical Chemistry, 90(21), 12527-12535. https://doi.org/10.1021/acs.analchem.8b02398

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Fornelli, L., Ayoub, D., Aizikov, K., Liu, X., Damoc, E., Pevzner, P. A., Makarov, A., Beck, A., & Tsybin, Y. O. (2017). Top-down analysis of immunoglobulin G isotypes 1 and 2 with electron transfer dissociation on a high-field Orbitrap mass spectrometer. Journal of Proteomics, 159, 67-76. https://doi.org/10.1016/j.jprot.2017.02.013

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Toby, T. K., Fornelli, L., & Kelleher, N. L. (2016). Progress in Top-Down Proteomics and the Analysis of Proteoforms. Annual Review of Analytical Chemistry, 9(1), 499-519. https://doi.org/10.1146/annurev-anchem-071015-041550

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Fornelli, L., Ayoub, D., Aizikov, K., Beck, A., & Tsybin, Y. O. (2014). Middle-down analysis of monoclonal antibodies with electron transfer dissociation orbitrap fourier transform mass spectrometry. Analytical Chemistry, 86(6), 3005-3012. https://doi.org/10.1021/ac4036857

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Fornelli, L., Damoc, E., Thomas, P. M., Kelleher, N. L., Aizikov, K., Denisov, E., Makarov, A., & Tsybin, Y. O. (2012). Analysis of Intact Monoclonal Antibody IgG1 by Electron Transfer Dissociation Orbitrap FTMS. Molecular & Cellular Proteomics, 11(12), 1758-1767. https://doi.org/10.1074/mcp.M112.019620

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