Mark Bothwell

. Bothwell, M. (2017) Mechanisms and Medicines for Remyelination, Ann. Rev. Medicine 68 431-443..

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. Bothwell, M. (2016) Recent advances in understanding neurotrophin signaling, F1000Res. 5-1885/v1

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. Meabon, J. S., De Laat, R., Ieguchi, K., Wiley, J. C., Hudson, M. P., and Bothwell, M. (2015) LINGO-1 Interacts with the p75 Neurotrophin Receptor in Intracellular Membrane Compartments. J. Biol. Chem. 290, 9511-9520

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. de Laat, R., Meabon, J.S., Wiley, J.C., Hudson, M.P., Montine, T.J. and Bothwel, M. (2015) LINGO-1 Promotes Lysosomal Degradation of Amyloid- Protein Precursor, Pathobiology of Aging & Age-related Disease 5 25796.

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. Meabon, J.S. de Laat, R., Ieguchi, K., Serbzhinsky, D., Hudson, M.P., Huber, B.R., Wiley, J.C. and Bothwell, M. (2015) Intracellular LINGO-1 Negatively Regulates Trk Neurotrophin Receptor Signaling, Mol. Cell. Neurosci., 70, 1-10.

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. Bothwell, M. Handb Exp Pharmacol (2014) NGF, BDNF, NT3, and NT4. 220:3-15.

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. Wang, Y., Sakano, H., Beebe, K. Brown, M.R., de Laat, R., Bothwell, M. Kulesza, R.J. and Rubr;, E.W. (2013) Intense and Specialized Dendritic Localization of the Fragile X Mental Retardation Protein in Binaural Brainstem Neurons-- a Comparative Study in the Alligator, Chicken, Gerbil, and Human. J. Comp. Neurol., in press.

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. Schecterson LC, Sanchez JT, Rubel EW, Bothwell M. (2012) TrkB downregulation is required for dendrite retraction in developing neurons of chicken nucleus magnocellularis. J Neurosci.32, p14000-09.

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. Schecterson LC, Bothwell M. Neurotrophin receptors: Old friends with new partners (2010) Dev Neurobiol. 70:332-338. PMC Journal - In Process

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. Wiley JC, Meabon JS, Frankowski H, Smith EA, Schecterson LC, Bothwell M, Ladiges WC. (2010) Phenylbutyric acid rescues endoplasmic reticulum stress-induced suppression of APP proteolysis and prevents apoptosis in neuronal cells. PLoS One. 5:e9135. PMCID: PMC2817752.

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. Schecterson LC, Hudson MP, Ko M, Philippidou P, Akmentin W, Wiley J, Rosenblum E, Chao MV, Halegoua S, Bothwell M. (2010) Trk activation in the secretory pathway promotes Golgi fragmentation. Mol Cell Neurosci. 43:403-413. PMC Journal - In Process

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. Mandai, K., Guo, T., St Hillaire, C., Meabon, J.S., Kanning, K.C., Bothwell, M., and Ginty, D.D. (2009). LIG family receptor tyrosine kinase-associated proteins modulate growth factor signals during neural development. Neuron 63, 614-627. PMCID: PMC2758028

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. Vilar, M., Charalampopoulos, I., Kenchappa, R.S., Simi, A., Karaca, E., Reversi, A., Choi, S., Bothwell, M., Mingarro, I., Friedman, W.J., Schiavo, G., Bastiaens, P.I., Verveer, P.J., Carter, B.D., and Ibanez, C.F. (2009). Activation of the p75 neurotrophin receptor through conformational rearrangement of disulphide-linked receptor dimers. Neuron 62, 72-83. PMCID: PMC2810632

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Garden, G.A., Canady, K.S., Lurie, D.I., Bothwell, M., and Rubel, E.W. (1994). A biphasic change in ribosomal conformation during transneuronal degeneration is altered by inhibition of mitochondrial, but not cytoplasmic protein synthesis. J Neurosci 14, 1994-2008

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. Hatch NE and Bothwell M (2008). "Crouzon Syndrome", Chapter in Encyclopedia of Molecular Mechanisms of Disease. Springer, New York, NY.

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. Schecterson, L.C., and Bothwell, M. (2008). An all-purpose tool for axon guidance. Science signaling 1, pe50

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. Bothwell, M. Neurotrophins and their Receptors (2008) in Handbook of Contemporary Neuropharmacology, John Wiley.

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. Wiley, J.C., Smith, E.A., Hudson, M.P., Ladiges, W.C., and Bothwell, M. (2007). Fe65 stimulates proteolytic liberation of the beta-amyloid precursor protein intracellular domain. The Journal of biological chemistry 282, 33313-33325

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. Bothwell, M. (2006). Evolution of the neurotrophin signaling system in invertebrates. Brain, behavior and evolution 68, 124-132

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. Hatch, N.E., Hudson, M., Seto, M.L., Cunningham, M.L., and Bothwell, M. (2006). Intracellular retention, degradation, and signaling of glycosylation-deficient FGFR2 and craniosynostosis syndrome-associated FGFR2C278F. The Journal of biological chemistry 281, 27292-27305

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. Hatch, N.E., Nociti, F., Swanson, E., Bothwell, M., and Somerman, M. (2005). FGF2 alters expression of the pyrophosphate/phosphate regulating proteins, PC-1, ANK and TNAP, in the calvarial osteoblastic cell line, MC3T3E1(C4). Connective tissue research 46, 184-192

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. Wiley, J.C., Hudson, M., Kanning, K.C., Schecterson, L.C., and Bothwell, M. (2005). Familial Alzheimer's disease mutations inhibit gamma-secretase-mediated liberation of beta-amyloid precursor protein carboxy-terminal fragment. Journal of neurochemistry 94, 1189-1201

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. Burke, M.A., and Bothwell, M. (2003). p75 neurotrophin receptor mediates neurotrophin activation of NF-kappa B and induction of iNOS expression in P19 neurons. Journal of neurobiology 55, 191-203

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. Kanning, K.C., Hudson, M., Amieux, P.S., Wiley, J.C., Bothwell, M., and Schecterson, L.C. (2003). Proteolytic processing of the p75 neurotrophin receptor and two homologs generates C-terminal fragments with signaling capability. J Neurosci 23, 5425-5436

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. Chao, M.V., and Bothwell, M. (2002). Neurotrophins: to cleave or not to cleave. Neuron 33, 9-12

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. Cramer, K.S., Karam, S.D., Bothwell, M., Cerretti, D.P., Pasquale, E.B., and Rubel, E.W. (2002). Expression of EphB receptors and EphrinB ligands in the developing chick auditory brainstem. The Journal of comparative neurology 452, 51-64

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. Iwamoto, S., Burrows, R.C., Grossniklaus, H.E., Orcutt, J., Kalina, R.E., Boehm, M., Bothwell, M.A., and Schmidt, R. (2002). Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas. Archives of ophthalmology 120, 1625-1629

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. Iwamoto, S., Burrows, R.C., Kalina, R.E., George, D., Boehm, M., Bothwell, M.A., and Schmidt, R. (2002). Immunophenotypic differences between uveal and cutaneous melanomas. Archives of ophthalmology 120, 466-470

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. Iwamoto S, Burrows RC, Grossniklaus HE, Orcutt J, Kalina RE, Boehm M, Bothwell MA, Schmidt R. Immunophenotype of conjunctival melanomas: comparisons with uveal and cutaneous melanomas (2002) Arch Ophthalmol. 120:1625-1629

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. Karam, S.D., Dottori, M., Ogawa, K., Henderson, J.T., Boyd, A.W., Pasquale, E.B., and Bothwell, M. (2002). EphA4 is not required for Purkinje cell compartmentation. Brain research 135, 29-38

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. Wong, S.T., Henley, J.R., Kanning, K.C., Huang, K.H., Bothwell, M., and Poo, M.M. (2002). A p75(NTR) and Nogo receptor complex mediates repulsive signaling by myelin-associated glycoprotein. Nature neuroscience 5, 1302-1308

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. Akbarian, S., Bates, B., Liu, R.J., Skirboll, S.L., Pejchal, T., Coppola, V., Sun, L.D., Fan, G., Kucera, J., Wilson, M.A., Tessarollo, L., Kosofsky, B.E., Taylor, J.R., Bothwell, M., Nestler, E.J., Aghajanian, G.K., and Jaenisch, R. (2001). Neurotrophin-3 modulates noradrenergic neuron function and opiate withdrawal. Molecular psychiatry 6, 593-604

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. Chalazonitis, A., Pham, T.D., Rothman, T.P., DiStefano, P.S., Bothwell, M., Blair-Flynn, J., Tessarollo, L., and Gershon, M.D. (2001). Neurotrophin-3 is required for the survival-differentiation of subsets of developing enteric neurons. J Neurosci 21, 5620-5636

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. Hutson, L.D., and Bothwell, M. (2001). Expression and function of Xenopus laevis p75(NTR) suggest evolution of developmental regulatory mechanisms. Journal of neurobiology 49, 79-98

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. Iwamoto, S., Burrows, R.C., Agoff, S.N., Piepkorn, M., Bothwell, M., and Schmidt, R. (2001). The p75 neurotrophin receptor, relative to other Schwann cell and melanoma markers, is abundantly Expressed in spindled melanomas. The American Journal of dermatopathology 23, 288-294

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. Karam, S.D., Kim, Y.S., and Bothwell, M. (2001). Granule cells migrate within raphes in the developing cerebellum: an evolutionarily conserved morphogenic event. The Journal of comparative neurology 440, 127-135

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Bothwell, M., and Giniger, E. (2000). Alzheimer's disease: neurodevelopment converges with neurodegeneration. Cell 102, 271-273

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Gunther, E.C., von Bartheld, C.S., Goodman, L.J., Johnson, J.E., and Bothwell, M. (2000). The G-protein inhibitor, pertussis toxin, inhibits the secretion of brain-derived neurotrophic factor. Neuroscience 100, 569-579

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Iwamoto, S., Burrows, R.C., Born, D.E., Piepkorn, M., and Bothwell, M. (2000). The application of direct immunofluorescence to intraoperative neurosurgical diagnosis. Biomolecular engineering 17, 17-22

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Karam, S.D., Burrows, R.C., Logan, C., Koblar, S., Pasquale, E.B., and Bothwell, M. (2000). Eph receptors and ephrins in the developing chick cerebellum: relationship to sagittal patterning and granule cell migration. J Neurosci 20, 6488-6500

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Bothwell, M. Neurotrophin Receptors (2000) in Neurotrophins, I. Marchetti editor, Sulzburger and Graham Publishing, 100. Koblar, S.A., Krull, C.E., Pasquale, E.B., McLennan, R., Peale, F.D., Cerretti, D.P., and Bothwell, M. (2000). Spinal motor axons and neural crest cells use different molecular guides for segmental migration through the rostral half-somite. Journal of neurobiology 42, 437-447

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. Woodnutt, D.A., Wager-Miller, J., O'Neill, P.C., Bothwell, M., and Byers, M.R. (2000). Neurotrophin receptors and nerve growth factor are differentially expressed in adjacent nonneuronal cells of normal and injured tooth pulp. Cell and tissue research 299, 225-236

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. Yuen, E.C., Gunther, E.C., and Bothwell, M. (2000). Nitric oxide activation of TrkB through peroxynitrite. Neuroreport 11, 3593-3597

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Mason, K., Peale, F.V., Jr., Stone, J.S., Rubel, E.W., and Bothwell, M. (1998). Expression of novel potassium channels in the chick basilar papilla. Hearing research 125, 120-130

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Peale, F.V., Jr., Mason, K., Hunter, A.W., and Bothwell, M. (1998). Multiplex display polymerase chain reaction amplifies and resolves related sequences sharing a single moderately conserved domain. Analytical biochemistry 256, 158-168

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Peale, F.V., Jr., Sugden, L., and Bothwell, M. (1998). Characterization of CMIX, a chicken homeobox gene related to the Xenopus gene mix.1. Mechanisms of development 75, 167-170

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Bothwell, M. (1997). Neurotrophin function in skin. The journal of investigative dermatology Symposium proceedings / the Society for Investigative Dermatology, Inc 2, 27-30

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Bothwell, M. (1996). p75NTR: a receptor after all. Science (New York, NY 272, 506-507

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Iwamoto, S., Odland, P.B., Piepkorn, M., and Bothwell, M. (1996). Evidence that the p75 neurotrophin receptor mediates perineural spread of desmoplastic melanoma. Journal of the American Academy of Dermatology 35, 725-731

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von Bartheld, C.S., Byers, M.R., Williams, R., and Bothwell, M. (1996). Anterograde transport of neurotrophins and axodendritic transfer in the developing visual system. Nature 379, 830-833

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von Bartheld, C.S., Williams, R., Lefcort, F., Clary, D.O., Reichardt, L.F., and Bothwell, M. (1996). Retrograde transport of neurotrophins from the eye to the brain in chick embryos: roles of the p75NTR and trkB receptors. J Neurosci 16, 2995-3008

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Bothwell, M. (1995). Functional interactions of neurotrophins and neurotrophin receptors. Annual review of neuroscience 18, 223-253

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Garden, G.A., Hartlage-Rubsamen, M., Rubel, E.W., and Bothwell, M.A. (1995). Protein masking of a ribosomal RNA epitope is an early event in afferent deprivation-induced neuronal death. Molecular and cellular neurosciences 6, 293-310

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von Bartheld, C.S., Schober, A., Kinoshita, Y., Williams, R., Ebendal, T., and Bothwell, M. (1995). Noradrenergic neurons in the locus coeruleus of birds express TrkA, transport NGF, and respond to NGF. J Neurosci 15, 2225-2239

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Borson, S., Schatteman, G., Claude, P., and Bothwell, M. (1994). Neurotrophins in the developing and adult primate adenohypophysis: a new pituitary hormone system? Neuroendocrinology 59, 466-476

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Fukuchi, K., Hearn, M.G., Deeb, S.S., Smith, A.C., Dang, N., Miyazaki, J., Bothwell, M., and Martin, G.M. (1994). Activity assays of nine heterogeneous promoters in neural and other cultured cells. In vitro cellular & developmental biology 30A, 300-305

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Henry, M.A., Westrum, L.E., Bothwell, M., and Press, S. (1994). Electron microscopic localization of nerve growth factor receptor (p75)-immunoreactivity in pars caudalis/medullary dorsal horn of the cat. Brain research 642, 137-145

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Schecterson, L.C., and Bothwell, M. (1994). Neurotrophin and neurotrophin receptor mRNA expression in developing inner ear. Hearing research 73, 92-100

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von Bartheld, C.S., Kinoshita, Y., Prevette, D., Yin, Q.W., Oppenheim, R.W., and Bothwell, M. (1994). Positive and negative effects of neurotrophins on the isthmo-optic nucleus in chick embryos. Neuron 12, 639-654

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Wheeler, E.F., Bothwell, M., Schecterson, L.C., and von Bartheld, C.S. (1994). Expression of BDNF and NT-3 mRNA in hair cells of the organ of Corti: quantitative analysis in developing rats. Hearing research 73, 46-56

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Alpers, C.E., Hudkins, K.L., Ferguson, M., Johnson, R.J., Schatteman, G.C., and Bothwell, M. (1993). Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys. Laboratory investigation; a journal of technical methods and pathology 69, 703-713

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Bothwell, M. Functional biology of neurotrophins.in Neurotrophic Factors, Taniguchi Symposium on Brain Sciences #15. (1993) Y. Tsukada and E. Shooter, Ed., CRC Press, Boca Raton, 71. Henry, M.A., Westrum, L.E., Bothwell, M., and Johnson, L.R. (1993). Nerve growth factor receptor (p75)-immunoreactivity in the normal adult feline trigeminal system and following retrogasserian rhizotomy. The Journal of comparative neurology 335, 425-436

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Keles, G.E., Berger, M.S., Schofield, D., and Bothwell, M. (1993). Nerve growth factor receptor expression in medulloblastomas and the potential role of nerve growth factor as a differentiating agent in medulloblastoma cell lines. Neurosurgery 32, 274-280; discussion 280

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Kinoshita, Y., Kinoshita, C., Heuer, J.G., and Bothwell, M. (1993). Basic fibroblast growth factor promotes adhesive interactions of neuroepithelial cells from chick neural tube with extracellular matrix proteins in culture. Development (Cambridge, England) 119, 943-956

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Patterson, S.L., Grady, M.S., and Bothwell, M. (1993). Nerve growth factor and a fibroblast growth factor-like neurotrophic activity in cerebrospinal fluid of brain injured human patients. Brain research 605, 43-49

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Schatteman, G.C., Langer, T., Lanahan, A.A., and Bothwell, M.A. (1993). Distribution of the 75-kD low-affinity nerve growth factor receptor in the primate peripheral nervous system. Somatosensory & motor research 10, 415-432

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von Bartheld, C.S., and Bothwell, M. (1993). Development of the mesencephalic nucleus of the trigeminal nerve in chick embryos: target innervation, neurotrophin receptors, and cell death. The Journal of comparative neurology 328, 185-202

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Byers, M.R., Kvinnsland, I., and Bothwell, M. (1992). Analysis of low affinity nerve growth factor receptor during pulpal healing and regeneration of myelinated and unmyelinated axons in replanted teeth. The Journal of comparative neurology 326, 470-484

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Byers, M.R., Wheeler, E.F., and Bothwell, M. (1992). Altered expression of NGF and P75 NGF-receptor by fibroblasts of injured teeth precedes sensory nerve sprouting. Growth factors (Chur, Switzerland) 6, 41-52

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Deyerle, K.L., Sims, J.E., Dower, S.K., and Bothwell, M.A. (1992). Pattern of IL-1 receptor gene expression suggests role in noninflammatory processes. J Immunol 149, 1657-1665

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von Bartheld, C. S. and Bothwell, M., (1992) Development of the mesencephalic nucleus of the trigeminal nerve in chick embryos: Target innervation, migration, neurotrophin receptors and cell death. J. Comp. Neurol. 326:1-26

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Mesulam, M.M., Mash, D., Hersh, L., Bothwell, M., and Geula, C. (1992). Cholinergic innervation of the human striatum, globus pallidus, subthalamic nucleus, substantia nigra, and red nucleus. The Journal of comparative neurology 323, 252-268

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Patterson, S.L., Grover, L.M., Schwartzkroin, P.A., and Bothwell, M. (1992). Neurotrophin expression in rat hippocampal slices: a stimulus paradigm inducing LTP in CA1 evokes increases in BDNF and NT-3 mRNAs. Neuron 9, 1081-1088

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Schecterson, L.C., and Bothwell, M. (1992). Novel roles for neurotrophins are suggested by BDNF and NT-3 mRNA expression in developing neurons. Neuron 9, 449-463

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Taiji, M., Taiji, K., Deyerle, K.L., and Bothwell, M. (1992). Basic fibroblast growth factor enhances nerve growth factor receptor gene promoter activity in human neuroblastoma cell line CHP100. Molecular and cellular biology 12, 2193-2202

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Vickland, H., Kott, J.N., Bothwell, M.A., and Westrum, L.E. (1992). Nerve growth factor receptor and the transplanted rat olfactory bulb. Experimental neurology 115, 137-141

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von Bartheld, C.S., and Bothwell, M. (1992). Development and distribution of noradrenergic and cholinergic neurons and their trophic phenotypes in the avian ceruleus complex and midbrain tegmentum. The Journal of comparative neurology 320, 479-500

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Wheeler, E.F., and Bothwell, M. (1992). Spatiotemporal patterns of expression of NGF and the low-affinity NGF receptor in rat embryos suggest functional roles in tissue morphogenesis and myogenesis. J Neurosci 12, 930-945

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Bothwell, M. (1991). Keeping track of neurotrophin receptors. Cell 65, 915-918

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Bothwell, M. (1991). Tissue localization of nerve growth factor and nerve growth factor receptors. Current topics in microbiology and immunology 165, 55-70

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Garden, G.A., Bothwell, M., and Rubel, E.W. (1991). Lack of correspondence between mRNA expression for a putative cell death molecule (SGP-2) and neuronal cell death in the central nervous system. Journal of neurobiology 22, 590-604

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Henry, M.A., Drangsholt, R.J., Westrum, L.E., and Bothwell, M. (1991). Localization of nerve growth factor receptor immunoreactivity in the trigeminal nucleus of kittens. Experimental neurology 113, 38-46

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Kullas, C.D., Henry, M.A., Westrum, L.E., Johnson, L.R., and Bothwell, M. (1991). Retrogasserian rhizotomy causes expression of nerve growth factor receptor-immunoreactive protein in motoneurons within the adult feline trigeminal motor nucleus. Neuroscience letters 126, 145-148

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Santos, P.M., Winterowd, J.G., Allen, G.G., Bothwell, M.A., and Rubel, E.W. (1991). Nerve growth factor: increased angiogenesis without improved nerve regeneration. Otolaryngol Head Neck Surg 105, 12-25

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Vickland, H., Westrum, L.E., Kott, J.N., Patterson, S.L., and Bothwell, M.A. (1991). Nerve growth factor receptor expression in the young and adult rat olfactory system. Brain research 565, 269-279

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Bothwell, M. Tissue localization of nerve growth factor and nerve growth factor receptors. (1991) Curr Top Microbiol Immunol.165:55-70, 56. von Bartheld, C.S., Heuer, J.G., and Bothwell, M. (1991). Expression of nerve growth factor (NGF) receptors in the brain and retina of chick embryos: comparison with cholinergic development. The Journal of comparative neurology 310, 103-129

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von Bartheld, C.S., Patterson, S.L., Heuer, J.G., Wheeler, E.F., Bothwell, M., and Rubel, E.W. (1991). Expression of nerve growth factor (NGF) receptors in the developing inner ear of chick and rat. Development (Cambridge, England) 113, 455-470

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Byers, M.R., Schatteman, G.C., and Bothwell, M. (1990). Multiple functions for NGF receptor in developing, aging and injured rat teeth are suggested by epithelial, mesenchymal and neural immunoreactivity. Development (Cambridge, England) 109, 461-471

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Heuer, J.G., Fatemie-Nainie, S., Wheeler, E.F., and Bothwell, M. (1990). Structure and developmental expression of the chicken NGF receptor. Developmental biology 137, 287-304

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Heuer, J.G., von Bartheld, C.S., Kinoshita, Y., Evers, P.C., and Bothwell, M. (1990). Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system. Neuron 5, 283-296

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Bothwell, M. Tissue localization of NGF and NGF receptors, Neuronal Growth Factors, (1990)M. Bothwell, ed. Springer-Verlag, Berlin.

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Kordower, J.H., Gash, D.M., Bothwell, M., Hersh, L., and Mufson, E.J. (1989). Nerve growth factor receptor and choline acetyltransferase remain colocalized in the nucleus basalis (Ch4) of Alzheimer's patients. Neurobiology of aging 10, 67-74

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Mesulam, M.M., Geula, C., Bothwell, M.A., and Hersh, L.B. (1989). Human reticular formation: cholinergic neurons of the pedunculopontine and laterodorsal tegmental nuclei and some cytochemical comparisons to forebrain cholinergic neurons. The Journal of comparative neurology 283, 611-633

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Bothwell, M., Growth factors. (1989) Textbook of Physiology, H.D. Patton et al., ed., Saunders, Philadelphia, 40. Mufson, E.J., Bothwell, M., Hersh, L.B., and Kordower, J.H. (1989). Nerve growth factor receptor immunoreactive profiles in the normal, aged human basal forebrain: colocalization with cholinergic neurons. The Journal of comparative neurology 285, 196-217

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Mufson, E.J., Bothwell, M., and Kordower, J.H. (1989). Loss of nerve growth factor receptor-containing neurons in Alzheimer's disease: a quantitative analysis across subregions of the basal forebrain. Experimental neurology 105, 221-232

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Sehgal, A., Bothwell, M., and Chao, M. (1989). Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts. Nucleic acids research 17, 5623-5632

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Thompson, S.J., Schatteman, G.C., Gown, A.M., and Bothwell, M. (1989). A monoclonal antibody against nerve growth factor receptor. Immunohistochemical analysis of normal and neoplastic human tissue. American journal of clinical pathology 92, 415-423

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Kordower, J.H., Bartus, R.T., Bothwell, M., Schatteman, G., and Gash, D.M. (1988). Nerve growth factor receptor immunoreactivity in the nonhuman primate (Cebus apella): distribution, morphology, and colocalization with cholinergic enzymes. The Journal of comparative neurology 277, 465-486

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Ross, A.H., Bothwell, M., Chao, M.V., Dietzschold, B. and Koprowski, H. Characterization and molecular cloning of the nerve growth factor receptor using monoclonal antibodies. (1988) In Molecular Structure of Receptors, A.D. Strasberg, ed. Ellis Horwood, Ltd., London, pp. 231-249, 36. Schatteman, G.C., Gibbs, L., Lanahan, A.A., Claude, P., and Bothwell, M. (1988). Expression of NGF receptor in the developing and adult primate central nervous system. J Neurosci 8, 860-873

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Marano, N., Dietzschold, B., Earley, J.J., Jr., Schatteman, G., Thompson, S., Grob, P., Ross, A.H., Bothwell, M., Atkinson, B.F., and Koprowski, H. (1987). Purification and amino terminal sequencing of human melanoma nerve growth factor receptor. Journal of neurochemistry 48, 225-232

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Bothwell, M., and Block, T. (1986). Use of iron- or selenium-coupled monoclonal antibodies to cell surface antigens as a positive selection system for cells. Methods in enzymology 121, 771-783

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Block, T. and Bothwell, M. "Nutrient-conjugated monoclonal antibodies for cell selection" (1986) in Biotechnology Handbook, P. Cherimisinoff, ed., Butterworth/Ann Arbor Science Publishers, 28. Breakefield, X.O., Ozelius, L., Bothwell, M.A., Chao, M.V., Axelrod, F., Kramer, P.L., Kidd, K.K., Lanahan, A.A., Johnson, D.E., Ross, A.H., and et al. (1986). DNA polymorphisms for the nerve growth factor receptor gene exclude its role in familial dysautonomia. Molecular biology & medicine 3, 483-494

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Chao, M.V., Bothwell, M.A., Ross, A.H., Koprowski, H., Lanahan, A.A., Buck, C.R., and Sehgal, A. (1986). Gene transfer and molecular cloning of the human NGF receptor. Science (New York, NY 232, 518-521

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Huebner, K., Isobe, M., Chao, M., Bothwell, M., Ross, A.H., Finan, J., Hoxie, J.A., Sehgal, A., Buck, C.R., Lanahan, A., and et al. (1986). The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias. Proceedings of the National Academy of Sciences of the United States of America 83, 1403-1407

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Johnson, D., Lanahan, A., Buck, C.R., Sehgal, A., Morgan, C., Mercer, E., Bothwell, M., and Chao, M. (1986). Expression and structure of the human NGF receptor. Cell 47, 545-554

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Ross, A.H., Herlyn, M., Maul, G.G., Koprowski, H., Bothwell, M., Chao, M., Pleasure, D., and Sonnenfeld, K.H. (1986). The nerve growth factor receptor in normal and transformed neural crest cells. Annals of the New York Academy of Sciences 486, 115-123

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Grob, P.M., Ross, A.H., Koprowski, H., and Bothwell, M. (1985). Characterization of the human melanoma nerve growth factor receptor. The Journal of biological chemistry 260, 8044-8049

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Bothwell, M. "Growth factors" in Encyclopedia of Science and Technology (1985) S. Parker, ed., McGraw-Hill

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Heidemann, S.R., Joshi, H.C., Schechter, A., Fletcher, J.R., and Bothwell, M. (1985). Synergistic effects of cyclic AMP and nerve growth factor on neurite outgrowth and microtubule stability of PC12 cells. The Journal of cell biology 100, 916-927

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Strazdis, J., Lanahan, A., Johnson, D.E., Bothwell, M., and Kucherlapati, R. (1985). The epidermal growth factor (EGF) receptor gene studied using gene transfer. The International journal of neuroscience 26, 129-140

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Ross, A.H., Grob, P., Bothwell, M., Elder, D.E., Ernst, C.S., Marano, N., Ghrist, B.F., Slemp, C.C., Herlyn, M., Atkinson, B., and et al. (1984). Characterization of nerve growth factor receptor in neural crest tumors using monoclonal antibodies. Proceedings of the National Academy of Sciences of the United States of America 81, 6681-6685

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Bothwell, M. "Mechanism of action of nerve growth factor" (1982) in Neuroscience Approached through Cell Culture, S. Pfeiffer, ed. CRC Press, Inc.: Boca Raton, pp. 51-68, 17. Block, T., and Bothwell, M. (1983). The nerve growth factor receptor on PC12 cells: interconversion between two forms with different binding properties. Journal of neurochemistry 40, 1654-1663

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Block, T., and Bothwell, M. (1983). Use of iron- or selenium-coupled monoclonal antibodies to cell-surface antigens as a positive selection system for cells. Nature 301, 342-344

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Grob, P.M., Berlot, C.H., and Bothwell, M.A. (1983). Affinity labeling and partial purification of nerve growth factor receptors from rat pheochromocytoma and human melanoma cells. Proceedings of the National Academy of Sciences of the United States of America 80, 6819-6823

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Grob, P.M., and Bothwell, M.A. (1983). Modification of nerve growth factor receptor properties by wheat germ agglutinin. The Journal of biological chemistry 258, 14136-14143

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Bothwell, M. (1982). Insulin and somatemedin MSA promote nerve growth factor-independent neurite formation by cultured chick dorsal root ganglionic sensory neurons. Journal of neuroscience research 8, 225-231

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Gunning, P.W., Landreth, G.E., Bothwell, M.A., and Shooter, E.M. (1981). Differential and synergistic actions of nerve growth factor and cyclic AMP in PC12 cells. The Journal of cell biology 89, 240-245

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Schechter, A.L., and Bothwell, M.A. (1981). Nerve growth factor receptors on PC12 cells: evidence for two receptor classes with differing cytoskeletal association. Cell 24, 867-874

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Bothwell, M.A., and Schachman, H.K. (1980). Equilibrium and kinetic studies of the association of catalytic and regulatory subunits of aspartate transcarbamoylase. The Journal of biological chemistry 255, 1962-1970

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Bothwell, M.A., and Schachman, H.K. (1980). A model for the assembly of aspartate transcarbamoylase from catalytic and regulatory subunits. The Journal of biological chemistry 255, 1971-1977

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Bothwell, M.A., Schechter, A.L., and Vaughn, K.M. (1980). Clonal variants of PC12 pheochromocytoma cells with altered response to nerve growth factor. Cell 21, 857-866

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Davies, R.L., Grosse, V.A., Kucherlapati, R., and Bothwell, M. (1980). Genetic analysis of epidermal growth factor action: assignment of human epidermal growth factor receptor gene to chromosome 7. Proceedings of the National Academy of Sciences of the United States of America 77, 4188-4192

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Harris-Warrick, R.M., Bothwell, M.A., and Shooter, E.M. (1980). Subunit interactions inhibit the binding of beta nerve growth factor to receptors on embryonic chick sensory neurons. The Journal of biological chemistry 255, 11284-11289

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Bothwell, M.A., Wilson, W.H., and Shooter, E.M. (1979). The relationship between glandular kallikrein and growth factor-processing proteases of mouse submaxillary gland. The Journal of biological chemistry 254, 7287-7294

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Bothwell, M.A., Howlett, G.J., and Schachman, H.K. (1978). A sedimentation equilibrium method for determining molecular weights of proteins with a tabletop high speed air turbine centrifuge. The Journal of biological chemistry 253, 2073-2077

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Bothwell, M.A., and Shooter, E.M. (1978). Thermodynamics of interaction of the subunits of 7 S nerve growth factor. The mechanism of activation of the esteropeptidase activity by chelators. The Journal of biological chemistry 253, 8458-8464

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Bothwell, M.A., and Shooter, E.M. (1977). Dissociation equilibrium constant of beta nerve growth factor. The Journal of biological chemistry 252, 8532-8536

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Subramani, S., Bothwell, M.A., Gibbons, I., Yang, Y.R., and Schachman, H.K. (1977). Ligand-promoted weakening of intersubunit bonding domains in aspartate transcarbamolylase. Proceedings of the National Academy of Sciences of the United States of America 74, 3777-3781

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Bothwell, M., and Schachman, H.K. (1974). Pathways of assembly of aspartate transcarbamoylase from catalytic and regulatory subunits. Proceedings of the National Academy of Sciences of the United States of America 71, 3221-3225

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Bothwell, M.A., and Datta, P. (1971). Effects of K+ on the catalytic and regulatory properties of homoserine dehydrogenase of Pseudomonas fluorescens. Biochimica et biophysica acta 235, 1-13

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