Nikhlesh Kumar Singh

Sharma A, Gupta DK, Bisen S, Singh NK. "Comparative evaluation of trypsin and elastase digestion techniques for isolation of murine retinal vasculature." (2024)

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Bisen S, Verma SK, Mukhopadhyay CS, Singh NK. "A neutrophil elastase-generated mature form of IL-33 is a potent regulator of endothelial cell activation and proliferative retinopathy." (2024)

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Kaur G, Sharma D, Bisen S, Mukhopadhyay CS, Gurdziel K, Singh NK. "Vascular cell-adhesion molecule 1 (VCAM-1) regulates JunB-mediated IL-8/CXCL1 expression and pathological neovascularization." (2023)

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Kaur G, Singh NK. "Inflammation and retinal degenerative diseases." (2023)

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Kaur G, Verma SK, Singh D, Singh NK. "Role of G-Proteins and GPCRs in Cardiovascular Pathologies." (2023)

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Sharma D, Singh NK. "The Biochemistry and Physiology of A Disintegrin and Metalloproteinases (ADAMs and ADAM-TSs) in Human Pathologies." (2023)

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Gogoi P, Kaur G, Singh NK. "Nanotechnology for colorectal cancer detection and treatment." (2022)

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Sharma D, Bisen S, Kaur G, Van Buren EC, Rao GN, Singh NK. "IL-33 enhances Jagged1 mediated NOTCH1 intracellular domain (NICD) deubiquitination and pathological angiogenesis in proliferative retinopathy." (2022)

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Kaur G, Singh NK. "The Role of Inflammation in Retinal Neurodegeneration and Degenerative Diseases." (2021)

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Sharma R, Sharma D, Hazlett LD, Singh NK. "Nano-Biomaterials for Retinal Regeneration." (2021)

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Boro M, Govatati S, Kumar R, Singh NK, Pichavaram P, Traylor JG Jr, Orr AW, Rao GN. "Thrombin-Par1 signaling axis disrupts COP9 signalosome subunit 3-mediated ABCA1 stabilization in inducing foam cell formation and atherogenesis." (2021)

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Kumar R, Mani AM, Singh NK, Rao GN. "PKCtheta-JunB axis via upregulation of VEGFR3 expression mediates hypoxia-induced pathological retinal neovascularization." (2020)

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Govatati S, Pichavaram P, Janjanam J, Zhang B, Singh NK, Mani AM, Traylor JG Jr, Orr AW, Rao GN. "NFATc1-E2F1-LMCD1-Mediated IL-33 Expression by Thrombin Is Required for Injury-Induced Neointima Formation." (2019)

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Pichavaram P, Mani AM, Singh NK, Rao GN. "Cholesterol crystals promote endothelial cell and monocyte interactions via H(2)O(2)-mediated PP2A inhibition, NFkappaB activation and ICAM1 and VCAM1 expression." (2019)

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Raghavan S, Singh NK, Gali S, Mani AM, Rao GN. "Response by Raghavan et al to Letter Regarding Article, "Protein Kinase Ctheta via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C(hi) Cells Contributes to Atherosclerosis"." (2019)

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Singh NK, Rao GN. "Emerging role of 12/15-Lipoxygenase (ALOX15) in human pathologies." (2019)

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Raghavan S, Singh NK, Gali S, Mani AM, Rao GN. "Protein Kinase Ctheta Via Activating Transcription Factor 2-Mediated CD36 Expression and Foam Cell Formation of Ly6C(hi) Cells Contributes to Atherosclerosis." (2018)

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Mani AM, Chattopadhyay R, Singh NK, Rao GN. "Cholesterol crystals increase vascular permeability by inactivating SHP2 and disrupting adherens junctions." (2018)

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Raghavan S, Singh NK, Mani AM, Rao GN. "Protease-activated receptor 1 inhibits cholesterol efflux and promotes atherogenesis via cullin 3-mediated degradation of the ABCA1 transporter." (2018)

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Janjanam J, Zhang B, Mani AM, Singh NK, Traylor JG Jr, Orr AW, Rao GN. "LIM and cysteine-rich domains 1 is required for thrombin-induced smooth muscle cell proliferation and promotes atherogenesis." (2018)

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Chattopadhyay R, Mani AM, Singh NK, Rao GN. "Resolvin D1 blocks H(2)O(2)-mediated inhibitory crosstalk between SHP2 and PP2A and suppresses endothelial-monocyte interactions." (2018)

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Kotla S, Singh NK, Kirchhofer D, Rao GN. "Heterodimers of the transcriptional factors NFATc3 and FosB mediate tissue factor expression for 15(S)-hydroxyeicosatetraenoic acid-induced monocyte trafficking." (2017)

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Singh NK, Janjanam J, Rao GN. "p115 RhoGEF activates the Rac1 GTPase signaling cascade in MCP1 chemokine-induced vascular smooth muscle cell migration and proliferation." (2017)

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Kotla S, Singh NK, Rao GN. "ROS via BTK-p300-STAT1-PPARgamma signaling activation mediates cholesterol crystals-induced CD36 expression and foam cell formation." (2017)

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Kumar R, Singh NK, Rao GN. "Proline-rich tyrosine kinase 2 via enhancing signal transducer and activator of transcription 3-dependent cJun expression mediates retinal neovascularization." (2016)

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Kumar R, Janjanam J, Singh NK, Rao GN. "A new role for cofilin in retinal neovascularization." (2016)

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Singh NK, Kotla S, Kumar R, Rao GN. "Cyclic AMP Response Element Binding Protein Mediates Pathological Retinal Neovascularization via Modulating DLL4-NOTCH1 Signaling." (2015)

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Singh NK, Kotla S, Dyukova E, Traylor JG Jr, Orr AW, Chernoff J, Marion TN, Rao GN. "Disruption of p21-activated kinase 1 gene diminishes atherosclerosis in apolipoprotein E-deficient mice." (2015)

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Chattopadhyay R, Tinnikov A, Dyukova E, Singh NK, Kotla S, Mobley JA, Rao GN. "12/15-Lipoxygenase-dependent ROS production is required for diet-induced endothelial barrier dysfunction." (2015)

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Kotla S, Singh NK, Traylor JG Jr, Orr AW, Rao GN. "ROS-dependent Syk and Pyk2-mediated STAT1 activation is required for 15(S)-hydroxyeicosatetraenoic acid-induced CD36 expression and foam cell formation." (2014)

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Chattopadhyay R, Dyukova E, Singh NK, Ohba M, Mobley JA, Rao GN. "Vascular endothelial tight junctions and barrier function are disrupted by 15(S)-hydroxyeicosatetraenoic acid partly via protein kinase C epsilon-mediated zona occludens-1 phosphorylation at threonine 770/772." (2014)

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Gadepalli R, Kotla S, Heckle MR, Verma SK, Singh NK, Rao GN. "Novel role for p21-activated kinase 2 in thrombin-induced monocyte migration." (2013)

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Kotla S, Singh NK, Heckle MR, Tigyi GJ, Rao GN. "The transcription factor CREB enhances interleukin-17A production and inflammation in a mouse model of atherosclerosis." (2013)

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Kundumani-Sridharan V, Singh NK, Kumar S, Gadepalli R, Rao GN. "Nuclear factor of activated T cells c1 mediates p21-activated kinase 1 activation in the modulation of chemokine-induced human aortic smooth muscle cell F-actin stress fiber formation, migration, and proliferation and injury-induced vascular wall remodeling." (2013)

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Singh NK, Hansen DE 3rd, Kundumani-Sridharan V, Rao GN. "Both Kdr and Flt1 play a vital role in hypoxia-induced Src-PLD1-PKCgamma-cPLA(2) activation and retinal neovascularization." (2013)

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Gadepalli R, Singh NK, Kundumani-Sridharan V, Heckle MR, Rao GN. "Novel role of proline-rich nonreceptor tyrosine kinase 2 in vascular wall remodeling after balloon injury." (2012)

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Singh NK, Kundumani-Sridharan V, Kumar S, Verma SK, Kotla S, Mukai H, Heckle MR, Rao GN. "Protein kinase N1 is a novel substrate of NFATc1-mediated cyclin D1-CDK6 activity and modulates vascular smooth muscle cell division and migration leading to inward blood vessel wall remodeling." (2012)

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Kundumani-Sridharan V, Van Quyen D, Subramani J, Singh NK, Chin YE, Rao GN. "Novel interactions between NFATc1 (Nuclear Factor of Activated T cells c1) and STAT-3 (Signal Transducer and Activator of Transcription-3) mediate G protein-coupled receptor agonist, thrombin-induced biphasic expression of cyclin D1, with first phase influencing cell migration and second phase directing cell proliferation." (2012)

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Singh NK, Kundumani-Sridharan V, Rao GN. "12/15-Lipoxygenase gene knockout severely impairs ischemia-induced angiogenesis due to lack of Rac1 farnesylation." (2011)

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Singh NK, Wang D, Kundumani-Sridharan V, Van Quyen D, Niu J, Rao GN. "15-Lipoxygenase-1-enhanced Src-Janus kinase 2-signal transducer and activator of transcription 3 stimulation and monocyte chemoattractant protein-1 expression require redox-sensitive activation of epidermal growth factor receptor in vascular wall remodeling." (2011)

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Zhang Q, Wang D, Singh NK, Kundumani-Sridharan V, Gadiparthi L, Rao ChM, Rao GN. "Activation of cytosolic phospholipase A2 downstream of the Src-phospholipase D1 (PLD1)-protein kinase C gamma (PKCgamma) signaling axis is required for hypoxia-induced pathological retinal angiogenesis." (2011)

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Singh NK, Quyen DV, Kundumani-Sridharan V, Brooks PC, Rao GN. "AP-1 (Fra-1/c-Jun)-mediated induction of expression of matrix metalloproteinase-2 is required for 15S-hydroxyeicosatetraenoic acid-induced angiogenesis." (2010)

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Kundumani-Sridharan V, Niu J, Wang D, Van Quyen D, Zhang Q, Singh NK, Subramani J, Karri S, Rao GN. "15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression." (2010)

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Kumar A, Singh NK, Sinha PR. "Inhibition of 1,2-dimethylhydrazine induced colon genotoxicity in rats by the administration of probiotic curd." (2010)

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Kumar A, Singh NK, Sinha PR, Kumar R. "Intervention of Acidophilus-casei dahi and wheat bran against molecular alteration in colon carcinogenesis." (2010)

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Potula HS, Wang D, Quyen DV, Singh NK, Kundumani-Sridharan V, Karpurapu M, Park EA, Glasgow WC, Rao GN. "Src-dependent STAT-3-mediated expression of monocyte chemoattractant protein-1 is required for 15(S)-hydroxyeicosatetraenoic acid-induced vascular smooth muscle cell migration." (2009)

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Karpurapu M, Wang D, Singh NK, Li Q, Rao GN. "NFATc1 targets cyclin A in the regulation of vascular smooth muscle cell multiplication during restenosis." (2008)

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