Research
Planarian Pharmacology
Molecular Vibrations
Nervous System
Neuropharmacological
Planaria
Regeneration Biology
Quantum Biology
Behavioral Response, Behavioral Responses
Animal Models, Animal Model, Animal Modeling
Undergraduate Research Experiences
Minimal Structural Requirements
Molecular Properties
Nicotinic Acetylcholine Receptor
List of Publications (49)
In 2024
49
The complexities of ligand/receptor interactions: Exploring the role of molecular vibrations and quantum tunnelling. OR Paga n BioEssays 46 (5), 2300195, 2024.
Found on Publication Page
48
Cotinine influences the effect of high and low nicotine concentrations on planarian motility differently. M Ruble, N Simpson, B Smith, W Adeshina, E Snyder, OR Paga n Neuroscience Letters 841, 137955, 2024.
Found on Publication Page
47
Schild analysis of the interaction between parthenolide and cocaine suggests an allosteric relationship for their effects on planarian motility. J Kakuturu, M O'Brien, OR Paga n Biomolecules 14 (9), 1168, 2024.
Found on Publication Page
In 2023
46
Influence of Microbiome on Withdrawal-Like Behavior in Planaria. EM Sosa, JM Pisciotta, M Guerra-Solano, O Pagan bioRxiv, 2023.09. 12.557338, 2023.
Found on Publication Page
In 2022
45
In vivo evaluation of the acute systemic toxicity of (1S, 2E, 4R, 6R, 7E, 11E)-Cembratriene-4, 6-diol (4R) in sprague dawley rats. N Sabeva, OR Paga n, Y Ferrer-Acosta, VA Eterovic , PA Ferchmin Nutraceuticals 2 (2), 60-70, 2022.
Found on Publication Page
44
Schild analysis of the interaction between parthenolide and cocaine on their effects on planarian motility suggests an orthosteric relationship. J Kakuturu, M O'Brien, OR Paga n .
Found on Publication Page
In 2021
43
Drunk Flies and Stoned Dolphins: A Trip Through the World of Animal Intoxication. OR Pagan BenBella Books, 2021.
Found on Publication Page
42
Endozepines in Insect Development and Metamorphosis. OR Paga n Naturally Occurring Benzodiazepines, Endozepines, and their Receptors, 89-97, 2021.
Found on Publication Page
In 2020
41
Measuring functional brain recovery in regenerating planarians by assessing the behavioral response to the cholinergic compound cytisine. OR Paga n, DL Baker, S Deats, M O'Brien, R Dymond, G DeMichele International Journal of Developmental Biology 64, 445, 2020.
Found on Publication Page
In 2019
40
The brain: a concept in flux. OR Paga n Philosophical Transactions of the Royal Society B 374 (1774), 20180383, 2019.
Found on Publication Page
39
Cotinine as a possible allosteric modulator of nicotine effects in various models. OR Paga n Neuroscience of nicotine, 57-63, 2019.
Found on Publication Page
In 2018
38
Strange survivors: how organisms attack and defend in the game of life. OR Paga n BenBella Books, 2018.
Found on Publication Page
In 2017
37
Planaria: an animal model that integrates development, regeneration and pharmacology. OR Paga n International Journal of Developmental Biology 61 (8-9), 519, 2017.
Found on Publication Page
In 2016
36
Cotinine antagonizes the behavioral effects of nicotine exposure in the planarian Girardia tigrina. DJ Bach, M Tenaglia, DL Baker, S Deats, E Montgomery, OR Paga n Neuroscience letters 632, 204-208, 2016.
Found on Publication Page
In 2015
35
Evidence of nicotine-induced, curare-insensitive, behavior in planarians. OR Paga n, E Montgomery, S Deats, D Bach, D Baker Neurochemical research 40, 2087-2090, 2015.
Found on Publication Page
In 2014
33
1 Why Do Plants Contain Biologically Active Compounds?. OR Paga n Kratom and Other Mitragynines, 1, 2014.
Found on Publication Page
32
The Voice of the Heart: A science fiction and autism story. OR Paga n Amazon Digital Services LLC, 2014.
Found on Publication Page
In 2013
31
Planarians require an intact brain to behaviorally react to cocaine, but not to react to nicotine. OR Paga n, S Deats, D Baker, E Montgomery, G Wilk, M Tenaglia, ... Neuroscience 246, 265-270, 2013.
Found on Publication Page
In 2012
30
Planarians in pharmacology: parthenolide is a specific behavioral antagonist of cocaine in the planarian Girardia tigrina. OR Paga n, D Baker, S Deats, E Montgomery, M Tenaglia, C Randolph, ... International Journal of Developmental Biology 56 (1-3), 193, 2012.
Found on Publication Page
In 2011
28
Parthenolide blocks cocaine's effect on spontaneous firing activity of dopaminergic neurons in the ventral tegmental area. D Schwarz, D Bloom, R Castro, O R Pagan, C A Jimenez-Rivera Current Neuropharmacology 9 (1), 17-20, 2011.
Found on Publication Page
27
Minimal structural requirements of alkyl -lactones capable of antagonizing the cocaine-induced motility decrease in planarians. D Baker, S Deats, P Boor, J Pruitt, OR Paga n Pharmacology Biochemistry and Behavior 100 (1), 174-179, 2011.
Found on Publication Page
In 2010
26
Minimal RNA aptamer sequences that can inhibit or alleviate noncompetitive inhibition of the muscle-type nicotinic acetylcholine receptor. K Sivaprakasam, OR Pagan, GP Hess Journal of Membrane Biology 233, 1-12, 2010.
Found on Publication Page
In 2009
25
A cembranoid from tobacco prevents the expression of nicotine-induced withdrawal behavior in planarian worms. OR Paga n, AL Rowlands, AL Fattore, T Coudron, KR Urban, AH Bidja, ... European journal of pharmacology 615 (1-3), 118-124, 2009.
Found on Publication Page
24
Actions of octocoral and tobacco cembranoids on nicotinic receptors. PA Ferchmin, OR Paga n, H Ulrich, AC Szeto, RM Hann, VA Eterovic Toxicon 54 (8), 1174-1182, 2009.
Found on Publication Page
23
The flatworm planaria as a toxicology and behavioral pharmacology animal model in undergraduate research experiences. OR Paga n, T Coudron, T Kaneria Journal of Undergraduate Neuroscience Education 7 (2), A48, 2009.
Found on Publication Page
In 2008
22
Reversal of cocaine-induced planarian behavior by parthenolide and related sesquiterpene lactones. OR Paga n, AL Rowlands, M Azam, KR Urban, AH Bidja, DM Roy, ... Pharmacology Biochemistry and Behavior 89 (2), 160-170, 2008.
Found on Publication Page
21
Parthenolide prevents the expression of cocaine-induced withdrawal behavior in planarians. AL Rowlands, OR Paga n European journal of pharmacology 583 (1), 170-172, 2008.
Found on Publication Page
In 2007
20
Molecular properties of local anesthetics as predictors of affinity for nicotinic acetylcholine receptors. OR Paga n, K Sivaprakasam, RE Oswald Journal of neuroscience research 85 (13), 2943-2949, 2007.
Found on Publication Page
19
Parthenolide alleviation of cocaine induced motility decrease in planaria. OR Pagan, KR Urban, AL Rowlands The FASEB Journal 21 (6), A778-A778, 2007.
Found on Publication Page
In 2006
18
Toxicity and behavioral effects of dimethylsulfoxide in planaria. OR Paga n, AL Rowlands, KR Urban Neuroscience letters 407 (3), 274-278, 2006.
Found on Publication Page
In 2005
17
Synthetic local anesthetics as alleviators of cocaine inhibition of the human dopamine transporter. OR Paga n Cornell University, 2005.
Found on Publication Page
16
Alleviation of cocaine inhibition of the human dopamine transporter. OR Pagan, GP Hess FASEB JOURNAL 19 (4), A514-A514, 2005.
Found on Publication Page
In 2003
15
Determination of the minimal structure of RNA polymers that prevent inhibition of the nicotinic acetylcholine receptor by cocaine. K Sivaprakasam, OR Pagan, GP Hess ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 225, U44-U44, 2003.
Found on Publication Page
In 2002
14
Tobacco cembranoids block the expression of the behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptors. VA Eterovic, PA Ferchmin, RM Hann, OR Pagan, AD Rodriguez, ... US Patent 6,489,357, 2002.
Found on Publication Page
13
Cembranoid and long-chain alkanol sites on the nicotinic acetylcholine receptor and their allosteric interaction (vol 40, pg 11121, 2001). OR Pagan, VA Eterovic, M Garcia, D Vergne, CM Basilio, AD Rodriguez, ... BIOCHEMISTRY 41 (9), 3278-3278, 2002.
Found on Publication Page
In 2001
12
Tobacco cembranoids block behavioral sensitization to nicotine and inhibit neuronal acetylcholine receptor function. PA Ferchmin, RJ Lukas, RM Hann, JD Fryer, JB Eaton, OR Pagan, ... Journal of neuroscience research 64 (1), 18-25, 2001.
Found on Publication Page
11
Cembranoid and long-chain alkanol sites on the nicotinic acetylcholine receptor and their allosteric interaction. OR Paga n, VA Eterovic , M Garcia, D Vergne, CM Basilio, AD Rodri guez, ... Biochemistry 40 (37), 11121-11130, 2001.
Found on Publication Page
10
Cembranoid inhibitors of nicotinic acetylcholine receptors. VA Eterovic, AD Rodriguez, RM Hann, PA Ferchmin, OR Pagan, MJ Eaton US Patent 6,204,289, 2001.
Found on Publication Page
In 1998
9
In vitro selection of RNA molecules that displace cocaine from the membrane-bound nicotinic acetylcholine receptor. H Ulrich, JE Ippolito, OR Paga n, VA Eterovic, RM Hann, H Shi, JT Lis, ... Proceedings of the National Academy of Sciences 95 (24), 14051-14056, 1998.
Found on Publication Page
8
Characterization of cembranoid interaction with the nicotinic acetylcholine receptor. RM Hann, OR Paga n, L Gregory, T Ja come, AD Rodri guez, PA Ferchmin, ... Journal of Pharmacology and Experimental Therapeutics 287 (1), 253-260, 1998.
Found on Publication Page
7
Cocaine-displaceable RNA aptamers bound to the nicotinic acetylcholine receptor. H Ulrich, JE Ippolito, OR Pagan, H Shi, JT Lis, GP Hess FASEB JOURNAL 12 (8), A1303-A1303, 1998.
Found on Publication Page
In 1997
6
The 9-arginine residue of -conotoxin GI is responsible for its selective high affinity for the agonist site on the electric organ acetylcholine receptor. RM Hann, OR Paga n, LM Gregory, T Ja come, VA Eterovic Biochemistry 36 (29), 9051-9056, 1997.
Found on Publication Page
5
Differential effects of dimethyl sulfoxide on nicotinic acetylcholine receptors from mouse muscle and Torpedo electrocytes. MJ Eaton, OR Paga n, RM Hann, VA Eterovic Neuroscience letters 230 (3), 163-166, 1997.
Found on Publication Page
4
N-methylcarbamoylcholine binding to the nicotinic acetylcholine receptor from Torpedo californica. OR Paqan, CM Basilio, RM Hann, T Jacome, LM Gregory, A Martino, ... JOURNAL OF NEUROCHEMISTRY 69, S73-S73, 1997.
Found on Publication Page
3
A midchain cationic residue is responsible for alpha-conotoxin high-affinity binding to the alpha gamma site on the electric organ acetylcholine receptor. RM Hann, OR Pagan, L Gregory, TJ Jacome, VA Eterovic JOURNAL OF NEUROCHEMISTRY 69, S74-S74, 1997.
Found on Publication Page
In 1994
2
The. alpha.-Conotoxins GI and MI Distinguish between the Nicotinic Acetylcholine Receptor Agonist Sites while SI Does Not. RM Hann, OR Pagan, VA Eterovic Biochemistry 33 (47), 14058-14063, 1994.
Found on Publication Page
1
ALPHA-CONOTOXIN SELECTIVITY AT ACETYLCHOLINE-RECEPTOR AGONIST SITES. RM HANN, OR PAGAN, VA ETEROVIC JOURNAL OF NEUROCHEMISTRY 62, S82-S82, 1994.
Found on Publication Page
