XIANGDONG LYU

Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors. X Lv, X Lu, J Cao, Q Luo, Y Ding, F Peng, A Pataer, D Lu, D Han, ... Science 381 (6662), eabn4180, 2023.

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Multiomics analyses reveal DARS1-AS1/YBX1-controlled posttranscriptional circuits promoting glioblastoma tumorigenesis/radioresistance. C Zheng, Y Wei, Q Zhang, M Sun, Y Wang, J Hou, P Zhang, X Lv, D Su, ... Science advances 9 (31), eadf3984, 2023.

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CRISPR/Cas9 screen uncovers functional translation of cryptic lncRNA-encoded open reading frames in human cancer. C Zheng, Y Wei, P Zhang, L Xu, Z Zhang, K Lin, J Hou, X Lv, Y Ding, ... The Journal of Clinical Investigation 133 (5), 2023.

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Systematic functional interrogation of human pseudogenes using CRISPRi. M Sun, Y Wang, C Zheng, Y Wei, J Hou, P Zhang, W He, X Lv, Y Ding, ... Genome biology 22, 1-29, 2021.

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Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte selection. X Liu, J Yu, L Xu, K Umphred-Wilson, F Peng, Y Ding, BM Barton, X Lv, ... Elife 10, e69975, 2021.

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Orthotopic transplantation of breast tumors as preclinical models for breast cancer. X Lv, LE Dobrolecki, Y Ding, JM Rosen, MT Lewis, X Chen Journal of visualized experiments: JoVE, 2020.

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Analysis on gene modular network reveals morphogen-directed development robustness in Drosophila. S Zhang, J Zhao, X Lv, J Fan, Y Lu, T Zeng, H Wu, L Chen, Y Zhao Cell discovery 6 (1), 43, 2020.

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Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit. L Cheng, X Zhang, Y Wang, H Gan, X Xu, X Lv, X Hua, J Que, T Ordog, ... Nucleic acids research 47 (21), 11114-11131, 2019.

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Pharmacological targeting of MYC-regulated IRE1/XBP1 pathway suppresses MYC-driven breast cancer. NA Zhao, J Cao, L Xu, Q Tang, LE Dobrolecki, X Lv, M Talukdar, Y Lu, ... The Journal of clinical investigation 128 (4), 1283-1299, 2018.

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Fsh-Pc-Sce complex mediates active transcription of Cubitus interruptus (Ci). X Lv, H Chen, S Zhang, Z Zhang, C Pan, Y Xia, J Fan, W Wu, Y Lu, ... Journal of molecular cell biology 10 (5), 437-447, 2018.

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Distinct functions of polycomb group proteins in regulating Ci transcription in developing Drosophila. X Lv, H Chen, S Zhang, Z Zhang, C Pan, Y Xia, J Fan, W Wu, Y Lu, ... Journal of Molecular Cell Biology 10 (5), 475-478, 2018.

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Repression of Abd-B by Polycomb is critical for cell identity maintenance in adult Drosophila testis. S Zhang, C Pan, X Lv, W Wu, H Chen, W Wu, H Wu, L Zhang, Y Zhao Scientific Reports 7 (1), 5101, 2017.

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UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. C Pan, Y Xiong, X Lv, Y Xia, S Zhang, H Chen, J Fan, W Wu, F Liu, H Wu, ... EMBO reports 18 (11), 1922-1934, 2017.

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A positive role for polycomb in transcriptional regulation via H4K20me1. X Lv, Z Han, H Chen, B Yang, X Yang, Y Xia, C Pan, L Fu, S Zhang, ... Cell research 26 (5), 529-542, 2016.

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SUMO regulates somatic cyst stem cell maintenance and directly targets the Hedgehog pathway in adult Drosophila testis. X Lv, C Pan, Z Zhang, Y Xia, H Chen, S Zhang, T Guo, H Han, H Song, ... Development 143 (10), 1655-1662, 2016.

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Gut-neuron interaction via Hh signaling regulates intestinal progenitor cell differentiation in Drosophila. H Han, C Pan, C Liu, X Lv, X Yang, Y Xiong, Y Lu, W Wu, J Han, Z Zhou, ... Cell discovery 1 (1), 1-13, 2015.

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Investigation of Protein-Protein Interactions and Conformational Changes in Hedgehog Signaling Pathway by FRET. L Fu, X Lv, Y Xiong, Y Zhao Hedgehog Signaling Protocols, 61-70, 2015.

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The Kto-Skd complex can regulate ptc expression by interacting with Cubitus interruptus (Ci) in the Hedgehog signaling pathway. F Mao, X Yang, L Fu, X Lv, Z Zhang, W Wu, S Yang, Z Zhou, L Zhang, ... Journal of Biological Chemistry 289 (32), 22333-22341, 2014.

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Ter94 ATPase complex targets k11-linked ubiquitinated ci to proteasomes for partial degradation. Z Zhang, X Lv, W Yin, X Zhang, J Feng, W Wu, C Hui, L Zhang, Y Zhao Developmental cell 25 (6), 636-644, 2013.

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Smoothened oligomerization/higher order clustering in lipid rafts is essential for high Hedgehog activity transduction. D Shi, X Lv, Z Zhang, X Yang, Z Zhou, L Zhang, Y Zhao Journal of Biological Chemistry 288 (18), 12605-12614, 2013.

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Activation of Smurf E3 ligase promoted by smoothened regulates hedgehog signaling through targeting patched turnover. S Huang, Z Zhang, C Zhang, X Lv, X Zheng, Z Chen, L Sun, H Wang, ... PLoS biology 11 (11), e1001721, 2013.

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Dual roles of Hh signaling in the regulation of somatic stem cell self-renewal and germline stem cell maintenance in Drosophila testis. Z Zhang, X Lv, J Jiang, L Zhang, Y Zhao Cell research 23 (4), 573-576, 2013.

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Drosophila Vps36 regulates Smo trafficking in Hedgehog signaling. X Yang, F Mao, X Lv, Z Zhang, L Fu, Y Lu, W Wu, Z Zhou, L Zhang, Y Zhao Journal of cell science 126 (18), 4230-4238, 2013.

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Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. Z Zhang, J Feng, C Pan, X Lv, W Wu, Z Zhou, F Liu, L Zhang, Y Zhao Journal of Cell Biology 203 (4), 575-583, 2013.

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aPKC / : a potential target for the therapy of Hh-dependent and Smo-inhibitor-resistant advanced BCC. X Lv, L Fu, Y Zhao Acta Biochim Biophys Sin 45 (7), 610-611, 2013.

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