Carol A Gilchrist

Profile Picture of Carol A Gilchrist
Title
Associate Professor
Department
Department of Medicine, Division of Infectious Diseases
Institution
University of Virginia

Education

  • PhD Molecular Biology

Research Interests

Parasitology   Trans Golgi   Apicomplexans  

  View all research interests

Biography

Globally an estimated one million children in low- and middle-income countries die before their fifth birthday from enteric infections that result in diarrhea. The virulence of the major causes of diarrheal illness in these settings, the protozoan parasites Entamoeba and Cryptosporidium, is highly variable. My hypothesis is that both parasite genetics and host environment factors control the virulent phenotype and my current focus is on the use of molecular methods to identify the approaches that would be most effective in preventing disease.

Homepages

Contact Information

  345 Crispell Dr Charlottesville VA22908

  4349245167

Research
Not mentioned yet. (?)
List of Publications (42)
In 2024
42

Ramakrishnan G, Young MK, Nayak U, Rigo I, Marrs AS, Gilchrist CA, Behm BW, Madden GR, Petri WA Jr. "Systemic neutrophil degranulation and emergency granulopoiesis in patients with Clostridioides difficile infection." (2024)

Found on Publication Page
In 2023
41

Carey M, Arju T, Cotton JA, Alam M, Kabir M, Faruque ASG, Haque R, Petri WA Jr, Gilchrist CA. "Genomic Heterogeneity of Cryptosporidium parvum Isolates From Children in Bangladesh: Implications for Parasite Biology and Human Infection." (2023)

Found on Publication Page
40

Petri WAO, Hossain B, Kabir M, So HH, Moreau GB, Nayak U, Ma JZ, Noor Z, Faruque A, Alum M, Haque R, Petri WA Jr, Gilchrist CA. "Children develop Immunity to cryptosporidiosis in a high transmission intensity area." (2023)

Found on Publication Page
39

Gilchrist CA, Campo JJ, Pablo JV, Ma JZ, Teng A, Oberai A, Shandling AD, Alam M, Kabir M, Faruque ASG, Haque R, Petri WA Jr. "Specific Cryptosporidium antigens associate with reinfection immunity and protection from cryptosporidiosis." (2023)

Found on Publication Page
In 2022
38

Saito-Nakano Y, Makiuchi T, Tochikura M, Gilchrist CA, Petri WA Jr, Nozaki T. "Corrigendum: ArfX2 GTPase Regulates Trafficking From the Trans-Golgi to Lysosomes and Is Necessary for Liver Abscess Formation in the Protozoan Parasite Entamoeba histolytica." (2022)

Found on Publication Page
In 2021
37

Saito-Nakano Y, Makiuchi T, Tochikura M, Gilchrist CA, Petri WA Jr, Nozaki T. "ArfX2 GTPase Regulates Trafficking From the Trans-Golgi to Lysosomes and Is Necessary for Liver Abscess Formation in the Protozoan Parasite Entamoeba histolytica." (2021)

Found on Publication Page
36

Kabir M, Alam M, Nayak U, Arju T, Hossain B, Tarannum R, Khatun A, White JA, Ma JZ, Haque R, Petri WA Jr, Gilchrist CA. "Nonsterile immunity to cryptosporidiosis in infants is associated with mucosal IgA against the sporozoite and protection from malnutrition." (2021)

Found on Publication Page
35

Carey MA, Medlock GL, Alam M, Kabir M, Uddin MJ, Nayak U, Papin J, Faruque ASG, Haque R, Petri WA, Gilchrist CA. "Megasphaera in the Stool Microbiota Is Negatively Associated With Diarrheal Cryptosporidiosis." (2021)

Found on Publication Page
34

Steiner KL, Kabir M, Hossain B, Gilchrist CA, Ma JZ, Ahmed T, Faruque ASG, Haque R, Petri WA. "Delayed Time to Cryptosporidiosis in Bangladeshi Children is Associated with Greater Fecal IgA against Two Sporozoite-Expressed Antigens." (2021)

Found on Publication Page
In 2020
33

Deichsel EL, Hillesland HK, Gilchrist CA, Naulikha JM, McGrath CJ, Van Voorhis WC, Rwigi D, Singa BO, Walson JL, Pavlinac PB. "Prevalence and Correlates of Cryptosporidium Infections in Kenyan Children With Diarrhea and Their Primary Caregivers." (2020)

Found on Publication Page
32

Steiner KL, Kabir M, Priest JW, Hossain B, Gilchrist CA, Cook H, Ma JZ, Korpe PS, Ahmed T, Faruque ASG, Haque R, Petri WA. "Fecal Immunoglobulin A Against a Sporozoite Antigen at 12 Months Is Associated With Delayed Time to Subsequent Cryptosporidiosis in Urban Bangladesh: A Prospective Cohort Study." (2020)

Found on Publication Page
In 2019
31

Donowitz JR, Parikh HI, Taniuchi M, Gilchrist CA, Haque R, Kirkpatrick BD, Alam M, Kakon SH, Islam BZ, Afreen S, Kabir M, Nayak U, Colgate ER, Carmolli MP, Petri WA Jr. "Increased Fecal Lactobacillus Is Associated With a Positive Glucose Hydrogen Breath Test in Bangladeshi Children." (2019)

Found on Publication Page
30

Gazi MA, Das S, Mahfuz M, Hasan MM, Hossain MS, Fahim SM, Alam MA, Noor Z, Gilchrist CA, Petri WA, Rahman MM, Mazumder RN, Haque R, Sarker SA, Ahmed T. "Screening for coeliac disease in children and adults living in a slum of Dhaka, Bangladesh." (2019)

Found on Publication Page
In 2018
29

Steiner KL, Ahmed S, Gilchrist CA, Burkey C, Cook H, Ma JZ, Korpe PS, Ahmed E, Alam M, Kabir M, Tofail F, Ahmed T, Haque R, Petri WA Jr, Faruque ASG. "Species of Cryptosporidia Causing Subclinical Infection Associated With Growth Faltering in Rural and Urban Bangladesh: A Birth Cohort Study." (2018)

Found on Publication Page
28

Kabir M, Ahmed E, Hossain B, Alam M, Ahmed S, Taniuchi M, Gilchrist CA, Houpt ER, Faruque ASG, Petri WA Jr, Haque R. "Giardia/Cryptosporidium QUIK CHEK Assay Is More Specific Than Quantitative Polymerase Chain Reaction for Rapid Point-of-care Diagnosis of Cryptosporidiosis in Infants in Bangladesh." (2018)

Found on Publication Page
27

Gilchrist CA, Cotton JA, Burkey C, Arju T, Gilmartin A, Lin Y, Ahmed E, Steiner K, Alam M, Ahmed S, Robinson G, Zaman SU, Kabir M, Sanders M, Chalmers RM, Ahmed T, Ma JZ, Haque R, Faruque ASG, Berriman M, Petri WA. "Genetic Diversity of Cryptosporidium hominis in a Bangladeshi Community as Revealed by Whole-Genome Sequencing." (2018)

Found on Publication Page
In 2017
26

Watanabe K, Gilchrist CA, Uddin MJ, Burgess SL, Abhyankar MM, Moonah SN, Noor Z, Donowitz JR, Schneider BN, Arju T, Ahmed E, Kabir M, Alam M, Haque R, Pramoonjago P, Mehrad B, Petri WA Jr. "Microbiome-mediated neutrophil recruitment via CXCR2 and protection from amebic colitis." (2017)

Found on Publication Page
25

Burgess SL, Gilchrist CA, Lynn TC, Petri WA Jr. "Parasitic Protozoa and Interactions with the Host Intestinal Microbiota." (2017)

Found on Publication Page
24

Ramakrishnan G, Wright M, Alam M, Naylor C, Kabir M, Zerin A, Ferdous T, Pedersen K, Hennig BJ, Donowitz JR, Wegmuller R, Haque R, Petri WA Jr, Herbein J, Gilchrist CA. "Rapid assessment of tetanus vaccine-induced immunity in Bangladesh and the Gambia." (2017)

Found on Publication Page
In 2016
23

Gilchrist CA. "The E. histolytica Genome Structure and Virulence." (2016)

Found on Publication Page
22

Spadafora LJ, Kearney MR, Siddique A, Ali IK, Gilchrist CA, Arju T, Hoffstrom B, Nguyen FK, Petri WA Jr, Haque R, Cangelosi GA. "Species-Specific Immunodetection of an Entamoeba histolytica Cyst Wall Protein." (2016)

Found on Publication Page
21

Gilchrist CA, Petri SE, Schneider BN, Reichman DJ, Jiang N, Begum S, Watanabe K, Jansen CS, Elliott KP, Burgess SL, Ma JZ, Alam M, Kabir M, Haque R, Petri WA Jr. "Role of the Gut Microbiota of Children in Diarrhea Due to the Protozoan Parasite Entamoeba histolytica." (2016)

Found on Publication Page
In 2015
20

Gilchrist CA, Turner SD, Riley MF, Petri WA Jr, Hewlett EL. "Whole-genome sequencing in outbreak analysis." (2015)

Found on Publication Page
19

Ramakrishnan G, Pedersen K, Guenette D, Sink J, Haque R, Petri WA Jr, Herbein J, Gilchrist CA. "Utility of recombinant fragment C for assessment of anti-tetanus antibodies in plasma." (2015)

Found on Publication Page
In 2014
18

Gilchrist CA. "Entamoeba bangladeshi: An insight." (2014)

Found on Publication Page
In 2013
17

Kato K, Takegawa Y, Ralston KS, Gilchrist CA, Hamano S, Petri WA Jr, Shinohara Y. "Sialic acid-dependent attachment of mucins from three mouse strains to Entamoeba histolytica." (2013)

Found on Publication Page
In 2012
16

Abhyankar MM, Shrimal S, Gilchrist CA, Bhattacharya A, Petri WA Jr. "The Entamoeba histolytica serum-inducible transmembrane kinase EhTMKB1-9 is involved in intestinal amebiasis." (2012)

Found on Publication Page
15

Gilchrist CA, Ali IK, Kabir M, Alam F, Scherbakova S, Ferlanti E, Weedall GD, Hall N, Haque R, Petri WA Jr, Caler E. "A Multilocus Sequence Typing System (MLST) reveals a high level of diversity and a genetic component to Entamoeba histolytica virulence." (2012)

Found on Publication Page
In 2011
14

Duggal P, Guo X, Haque R, Peterson KM, Ricklefs S, Mondal D, Alam F, Noor Z, Verkerke HP, Marie C, Leduc CA, Chua SC Jr, Myers MG Jr, Leibel RL, Houpt E, Gilchrist CA, Sher A, Porcella SF, Petri WA Jr. "A mutation in the leptin receptor is associated with Entamoeba histolytica infection in children." (2011)

Found on Publication Page
In 2010
13

Abhyankar MM, Haviland SM, Gilchrist CA, Petri WA Jr. "Development of a negative selectable marker for Entamoeba histolytica." (2010)

Found on Publication Page
12

Gilchrist CA, Moore ES, Zhang Y, Bousquet CB, Lannigan JA, Mann BJ, Petri WA. "Regulation of Virulence of Entamoeba histolytica by the URE3-BP Transcription Factor." (2010)

Found on Publication Page
11

Buss SN, Hamano S, Vidrich A, Evans C, Zhang Y, Crasta OR, Sobral BW, Gilchrist CA, Petri WA Jr. "Members of the Entamoeba histolytica transmembrane kinase family play non-redundant roles in growth and phagocytosis." (2010)

Found on Publication Page
10

Moreno H, Linford AS, Gilchrist CA, Petri WA Jr. "Phospholipid-binding protein EhC2A mediates calcium-dependent translocation of transcription factor URE3-BP to the plasma membrane of Entamoeba histolytica." (2010)

Found on Publication Page
In 2009
9

Gilchrist CA, Petri WA Jr. "Using differential gene expression to study Entamoeba histolytica pathogenesis." (2009)

Found on Publication Page
8

Abhyankar MM, Hochreiter AE, Connell SK, Gilchrist CA, Mann BJ, Petri WA Jr. "Development of the Gateway system for cloning and expressing genes in Entamoeba histolytica." (2009)

Found on Publication Page
In 2008
7

Gilchrist CA, Baba DJ, Zhang Y, Crasta O, Evans C, Caler E, Sobral BW, Bousquet CB, Leo M, Hochreiter A, Connell SK, Mann BJ, Petri WA. "Targets of the Entamoeba histolytica transcription factor URE3-BP." (2008)

Found on Publication Page
6

Abhyankar MM, Hochreiter AE, Hershey J, Evans C, Zhang Y, Crasta O, Sobral BW, Mann BJ, Petri WA Jr, Gilchrist CA. "Characterization of an Entamoeba histolytica high-mobility-group box protein induced during intestinal infection." (2008)

Found on Publication Page
In 2006
5

Gilchrist CA, Houpt E, Trapaidze N, Fei Z, Crasta O, Asgharpour A, Evans C, Martino-Catt S, Baba DJ, Stroup S, Hamano S, Ehrenkaufer G, Okada M, Singh U, Nozaki T, Mann BJ, Petri WA Jr. "Impact of intestinal colonization and invasion on the Entamoeba histolytica transcriptome." (2006)

Found on Publication Page
In 2005
4

Ng CT, Gilchrist CA, Lane A, Roy S, Haque R, Houpt ER. "Multiplex real-time PCR assay using Scorpion probes and DNA capture for genotype-specific detection of Giardia lamblia on fecal samples." (2005)

Found on Publication Page
In 2004
3

Ramakrishnan G, Gilchrist CA, Musa H, Torok MS, Grant PA, Mann BJ, Petri WA Jr. "Histone acetyltransferases and deacetylase in Entamoeba histolytica." (2004)

Found on Publication Page
In 2003
2

Gilchrist CA, Leo M, Line CG, Mann BJ, Petri WA Jr. "Calcium modulates promoter occupancy by the Entamoeba histolytica Ca2+-binding transcription factor URE3-BP." (2003)

Found on Publication Page
In 2002
1

Singh U, Gilchrist CA, Schaenman JM, Rogers JB, Hockensmith JW, Mann BJ, Petri WA. "Context-dependent roles of the Entamoeba histolytica core promoter element GAAC in transcriptional activation and protein complex assembly." (2002)

Found on Publication Page
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