Research
Brain Function
Aerobic Exercise Training
Late Middle
Adult Neurogenesis
Conditioned Media
Synaptic Plasticity
One Week
Knockout Mice
Behavioral Deficit, Behavioral Deficits
Frontotemporal Dementia
Mouse Model, Mouse Models
Male Mice
Cognitive Impairment, Cognitive Impairments
Neuronal Networks, Neuronal Network
Old Age
Physical Exercise
Brain Plasticity
Functional Circuits
Human Model, Human Models
Spatial Memory
Symptom Onset
Environmental Enrichment
Viral Particles
Alzheimer Pathology
Animal Models, Animal Model, Animal Modeling
Brain Aging
Growth Factor, Growth Factors
Middle Aged, Middle Age, Middle Ages
Molecular Changes
Tumor Necrosis Factor
Bone Marrow
Synapse Formation
High Levels
Gene Expression
Behavioral Neuroscience
Adult Brain
Stem Cell Research
Ataxia Telangiectasia
Drug Targets
Physical Activity, Physical Activities, Physically Active
Entorhinal Cortex
Lentiviral Vectors
Neural Consequences
Neuronal Plasticity
Self Repair
List of Publications (89)
In 2023
In 2022
In 2021
87
Effects of Combined Anti-Hypertensive and Statin Treatment on Memory, Fear Extinction, Adult Neurogenesis, and Angiogenesis in Adult and Middle-Aged Mice (2021)
Found on Publication Page
86
Lee, T.H. and Christie, B.R. and van Praag, H. and Lin, K. and Siu, P.M.-F. and Xu, A. and So, K.-F. and Yau, S.-Y. "Adiporon treatment induces a dose dependent response in adult hippocampal neurogenesis" (2021)
Found on Publication Page
85
Gait{\'a}n, J.M. and Moon, H.Y. and Stremlau, M. and Dubal, D.B. and Cook, D.B. and Okonkwo, O.C. and van Praag, H. "Effects of Aerobic Exercise Training on Systemic Biomarkers and Cognition in Late Middle-Aged Adults at Risk for Alzheimer's Disease" (2021)
Found on Publication Page
In 2020
84
Schweppe, C.A. and Burzynski, C. and Jayanthi, S. and Ladenheim, B. and Cadet, J.L. and Gardner, E.L. and Xi, Z.-X. and van Praag, H. and Newman, A.H. and Keck, T.M. "Neurochemical and behavioral comparisons of contingent and non-contingent methamphetamine exposure following binge or yoked long-access self-administration paradigms" (2020)
Found on Publication Page
82
Zhao, X. and van Praag, H. "Steps towards standardized quantification of adult neurogenesis" (2020)
Found on Publication Page
81
Joo, Y. and Xue, Y. and Wang, Y. and McDevitt, R.A. and Sah, N. and Bossi, S. and Su, S. and Lee, S.K. and Peng, W. and Xie, A. and Zhang, Y. and Ding, Y. and Ku, W.L. and Ghosh, S. and Fishbein, K. and Shen, W. and Spencer, R. and Becker, K. and Zhao, K. and Mattson, M.P. and van Praag, H. and Sharov, A. and Wang, W. "Topoisomerase 3 knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity" (2020)
Found on Publication Page
In 2019
80
Terreros-Roncal, J. and Flor-Garc{\'i}a, M. and Moreno-Jim{\'e}nez, E.P. and Pallas-Bazarra, N. and R{\'a}bano, A. and Sah, N. and Van Praag, H. and Giacomini, D. and Schinder, A.F. and ?vila, J. and Llorens-Mart{\'i}n, M. "Activity-dependent reconnection of adult-born dentate granule cells in a mouse model of frontotemporal dementia" (2019)
Found on Publication Page
79
Moon, H.Y. and Javadi, S. and Stremlau, M. and Yoon, K.J. and Becker, B. and Kang, S.-U. and Zhao, X. and van Praag, H. "Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells" (2019)
Found on Publication Page
78
Voss, M.W. and Soto, C. and Yoo, S. and Sodoma, M. and Vivar, C. and van Praag, H. "Exercise and Hippocampal Memory Systems" (2019)
Found on Publication Page
77
Shen, M. and Wang, F. and Li, M. and Sah, N. and Stockton, M.E. and Tidei, J.J. and Gao, Y. and Korabelnikov, T. and Kannan, S. and Vevea, J.D. and Chapman, E.R. and Bhattacharyya, A. and van Praag, H. and Zhao, X. "Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice" (2019)
Found on Publication Page
In 2018
76
Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells. (2018)
Found on Publication Page
75
Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model (2018)
Found on Publication Page
74
Mohammad, H. and Marchisella, F. and Ortega-Martinez, S. and Hollos, P. and Eerola, K. and Komulainen, E. and Kulesskaya, N. and Freemantle, E. and Fagerholm, V. and Savontous, E. and Rauvala, H. and Peterson, B.D. and Van Praag, H. and Coffey, E.T. "JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche" (2018)
Found on Publication Page
In 2017
70
Jongbloets, B.C. and Lemstra, S. and Schellino, R. and Broekhoven, M.H. and Parkash, J. and Hellemons, A.J.C.G.M. and Mao, T. and Giacobini, P. and Van Praag, H. and De Marchis, S. and Ramakers, G.M.J. and Pasterkamp, R.J. "Stage-specific functions of Semaphorin7A during adult hippocampal neurogenesis rely on distinct receptors" (2017)
Found on Publication Page
In 2016
68
Duzel, E. and Van Praag, H. and Sendtner, M. "Can physical exercise in old age improve memory and hippocampal function?" (2016)
Found on Publication Page
67
Tweedie, D. and Fukui, K. and Li, Y. and Yu, Q.-S. and Barak, S. and Tamargo, I.A. and Rubovitch, V. and Holloway, H.W. and Lehrmann, E. and Wood, W.H. and Zhang, Y. and Becker, K.G. and Perez, E. and Van Praag, H. and Luo, Y. and Hoffer, B.J. and Becker, R.E. and Pick, C.G. and Greig, N.H. "Cognitive impairments induced by concussive mild traumatic brain injury in mouse are ameliorated by treatment with phenserine via multiple non-cholinergic and cholinergic mechanisms" (2016)
Found on Publication Page
66
Vivar, C. and Peterson, B.D. and van Praag, H. "Running rewires the neuronal network of adult-born dentate granule cells" (2016)
Found on Publication Page
65
Moon, H.Y. and Becke, A. and Berron, D. and Becker, B. and Sah, N. and Benoni, G. and Janke, E. and Lubejko, S.T. and Greig, N.H. and Mattison, J.A. and Duzel, E. and van Praag, H. "Running-Induced Systemic Cathepsin B Secretion Is Associated with Memory Function" (2016)
Found on Publication Page
In 2015
64
Guerrieri, D. and van Praag, H. "Exercise-mimetic AICAR transiently benefits brain function" (2015)
Found on Publication Page
63
Zhang, Z. and van Praag, H. "Maternal immune activation differentially impacts mature and adult-born hippocampal neurons in male mice" (2015)
Found on Publication Page
62
Stringer, T.P. and Guerrieri, D. and Vivar, C. and Van Praag, H. "Plant-derived flavanol (-)epicatechin mitigates anxiety in association with elevated hippocampal monoamine and BDNF levels, but does not influence pattern separation in mice" (2015)
Found on Publication Page
In 2014
61
Kobilo, T. and Guerrieri, D. and Zhang, Y. and Collica, S.C. and Becker, K.G. and Van Praag, H. "AMPK agonist AICAR improves cognition and motor coordination in young and aged mice" (2014)
Found on Publication Page
In 2013
59
Voss, M.W. and Vivar, C. and Kramer, A.F. and van Praag, H. "Bridging animal and human models of exercise-induced brain plasticity" (2013)
Found on Publication Page
57
Barak, B. and Okun, E. and Ben-Simon, Y. and Lavi, A. and Shapira, R. and Madar, R. and Wang, Y. and Norman, E. and Sheinin, A. and Pita, M.A. and Yizhar, O. and Mughal, M.R. and Stuenkel, E. and Van Praag, H. and Mattson, M.P. and Ashery, U. "Neuron-specific expression of tomosyn1 in the mouse hippocampal dentate gyrus impairs spatial learning and memory" (2013)
Found on Publication Page
56
Marlatt, M.W. and Potter, M.C. and Bayer, T.A. and van Praag, H. and Lucassen, P.J. "Prolonged running, not fluoxetine treatment, increases neurogenesis, but does not alter neuropathology, in the 3xTg mouse model of alzheimer's disease" (2013)
Found on Publication Page
In 2012
55
Vivar, C. and Potter, M.C. and van Praag, H. "All about running: Synaptic plasticity, growth factors and adult hippocampal neurogenesis" (2012)
Found on Publication Page
54
Wang, Z. and Van Praag, H. "Exercise and the brain: Neurogenesis, synaptic plasticity, spine density, and angiogenesis" (2012)
Found on Publication Page
53
Gleichmann, M. and Zhang, Y. and Wood, W.H. and Becker, K.G. and Mughal, M.R. and Pazin, M.J. and van Praag, H. and Kobilo, T. and Zonderman, A.B. and Troncoso, J.C. and Markesbery, W.R. and Mattson, M.P. "Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks" (2012)
Found on Publication Page
52
Vivar, Carmen and Potter, Michelle C. and Choi, Jiwon and Lee, Ji-young and Stringer, Thomas P. and Callaway, Edward M. and Gage, Fred H. and Suh, Hoonkyo and van Praag, Henriette. "Monosynaptic inputs to new neurons in the dentate gyrus" (2012)
Found on Publication Page
50
Marlatt, Michael W. and Potter, Michelle C. and Lucassen, Paul J. and van Praag, Henriette. "Running throughout middle-age improves memory function, hippocampal neurogenesis, and BDNF levels in female C57BL/6J mice" (2012)
Found on Publication Page
49
Tweedie, D. and Ferguson, R.A. and Fishman, K. and Frankola, K.A. and Van Praag, H. and Holloway, H.W. and Luo, W. and Li, Y. and Caracciolo, L. and Russo, I. and Barlati, S. and Ray, B. and Lahiri, D.K. and Bosetti, F. and Greig, N.H. and Rosi, S. "Tumor necrosis factor- synthesis inhibitor 3,6'-dithiothalidomide attenuates markers of inflammation, Alzheimer pathology and behavioral deficits in animal models of neuroinflammation and Alzheimer's disease" (2012)
Found on Publication Page
In 2011
48
Kobilo, T. and Yuan, C. and Van Praag, H. "Endurance factors improve hippocampal neurogenesis and spatial memory in mice" (2011)
Found on Publication Page
47
Kobilo, T. and Liu, Q.R. and Gandhi, K. and Mughal, M. and Shaham, Y. and van Praag, H. "Running is the neurogenic and neurotrophic stimulus in environmental enrichment." (2011)
Found on Publication Page
46
Kannangara, Timal S. and Lucero, Melanie J. and Gil-Mohapel, Joana and Drapala, Robert J. and Simpson, Jessica M. and Christie, Brian R. and van Praag, Henriette. "Running reduces stress and enhances cell genesis in aged mice" (2011)
Found on Publication Page
45
Cockrell, A.S. and van Praag, H. and Santistevan, N. and Ma, H. and Kafri, T. "The HIV-1 Rev/RRE system is required for HIV-1 5' UTR cis elements to augment encapsidation of heterologous RNA into HIV-1 viral particles." (2011)
Found on Publication Page
In 2010
44
Marlatt, Michael W. and Lucassen, Paul J. and van Praag, Henriette. "Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice" (2010)
Found on Publication Page
43
Potter, M.C. and Yuan, C. and Ottenritter, C. and Mughal, M. and van Praag, H. "Exercise is not beneficial and may accelerate symptom onset in a mouse model of Huntington's disease" (2010)
Found on Publication Page
41
Yuen, E.Y. and Liu, W. and Kafri, T. and van Praag, H. and Yan, Z. "Regulation of AMPA receptor channels and synaptic plasticity by cofilin phosphatase Slingshot in cortical neurons" (2010)
Found on Publication Page
40
Creer, D.J. and Romberg, C. and Saksida, L.M. and Van Praag, H. and Bussey, T.J. "Running enhances spatial pattern separation in mice" (2010)
Found on Publication Page
39
Okun, E. and Griffioen, K.J. and Gen Son, T. and Lee, J.-H. and Roberts, N.J. and Mughal, M.R. and Hutchison, E. and Cheng, A. and Arumugam, T.V. and Lathia, J.D. and Van Praag, H. and Mattson, M.P. "TLR2 activation inhibits embryonic neural progenitor cell proliferation" (2010)
Found on Publication Page
38
Lazarov, O. and Mattson, M.P. and Peterson, D.A. and Pimplikar, S.W. and van Praag, H. "When neurogenesis encounters aging and disease" (2010)
Found on Publication Page
In 2009
In 2008
In 2007
34
Van Praag, H. and Lucero, M.J. and Yeo, G.W. and Stecker, K. and Heivand, N. and Zhao, C. and Yip, E. and Afanador, M. and Schroeter, H. and Hammerstone, J. and Gage, F.H. "Erratum: Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice (Journal of Neuroscience (2007) (5869-5878))" (2007)
Found on Publication Page
33
Van Praag, H. and Lucero, M.J. and Yeo, G.W. and Stecker, K. and Heivand, N. and Zhao, C. and Yip, E. and Afanador, M. and Schroeter, H. and Hammerstone, J. and Gage, F.H. "Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice" (2007)
Found on Publication Page
32
Toni, Nicolas and Teng, E Matthew and Bushong, Eric A and Aimone, James B and Zhao, Chunmei and Consiglio, Antonella and van Praag, Henriette and Martone, Maryann E and Ellisman, Mark H and Gage, Fred H. "Synapse formation on neurons born in the adult hippocampus" (2007)
Found on Publication Page
In 2006
31
Laplagne, Diego A. and EspA 3sito, M. Soledad and Piatti, VerA 3nica C. and Morgenstern, NicolA s A. and Zhao, Chunmei and van Praag, Henriette and Gage, Fred H. and Schinder, Alejandro F. "Functional Convergence of Neurons Generated in the Developing and Adult Hippocampus" (2006)
Found on Publication Page
In 2005
30
Galimi, F. and Summers, R.G. and Van Praag, H. and Verma, I.M. and Gage, F.H. "A role for bone marrow-derived cells in the vasculature of noninjured CNS" (2005)
Found on Publication Page
29
Van Praag, H. and Shubert, T. and Zhao, C. and Gage, F.H. "Exercise enhances learning and hippocampal neurogenesis in aged mice" (2005)
Found on Publication Page
In 2004
28
Farmer, J. and Zhao, X. and Van Praag, H. and Wodtke, K. and Gage, F.H. and Christie, B.R. "Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male sprague-dawley rats in vivo" (2004)
Found on Publication Page
27
Rhodes, J.S. and Van Praag, H. and Jeffrey, S. and Girard, I. and Mitchell, G.S. and Garland Jr., T. and Gage, F.H. "Erratum: "Exercise Increases Hippocampal Neurogenesis to High Levels but Does Not Improve Spatial Learning in Mice Bred for Increased Voluntary Wheel Running" (Behavioral Neuroscience (2003) 117, 5 (1006-1016))" (2004)
Found on Publication Page
In 2003
26
Brown, Jason and Cooper-Kuhn, Christiana M. and Kempermann, Gerd and Van Praag, Henriette and Winkler, Jurgen and Gage, Fred H. and Kuhn, H. Georg. "Enriched environment and physical activity stimulate hippocampal but not olfactory bulb neurogenesis" (2003)
Found on Publication Page
25
Rhodes, J.S. and Jeffrey, S. and Girard, I. and Mitchell, G.S. and Van Praag, H. and Garland Jr., T. and Gage, F.H. "Exercise increases hippocampal neurogenesis to high levels but does not improve spatial learning in mice bred for increased voluntary wheel running" (2003)
Found on Publication Page
In 2002
24
van Praag, Henriette and Schinder, Alejandro F. and Christie, Brian R. and Toni, Nicolas and Palmer, Theo D. and Gage, Fred H. "Functional neurogenesis in the adult hippocampus" (2002)
Found on Publication Page
23
Van Praag, H. and Gage, F.H. and Lombroso, P. "Genetics of Childhood Disorders: XXXVI. Stem Cell Research, Part 1: New Neurons in the Adult Brain" (2002)
Found on Publication Page
In 2001
22
Van Praag, H. and Barlow, C. and Gage, F.H. "Are drug targets missed owing to lack of physical activity? - Reply" (2001)
Found on Publication Page
21
Allen, D.M. and Van Praag, H. and Ray, J. and Weaver, Z. and Winrow, C.J. and Carter, T.A. and Braquet, R. and Harrington, E. and Ried, T. and Brown, K.D. and Gage, F.H. and Barlow, C. "Ataxia telangiectasia mutated is essential during adult neurogenesis" (2001)
Found on Publication Page
In 2000
20
Kempermann, G. and Van Praag, H. and Gage, F.H. "Activity-dependent regulation of neuronal plasticity and self repair" (2000)
Found on Publication Page
19
Jacobs, B.L. and Van Praag, H. and Gage, F.H. "Adult brain neurogenesis and psychiatry: A novel theory of depression" (2000)
Found on Publication Page
18
Jacobs, B.L. and Van Praag, H. and Gage, F.H. "Depression and the birth and death of brain cells" (2000)
Found on Publication Page
17
Kafri, T. and Van Praag, H. and Gage, F.H. and Verma, I.M. "Lentiviral vectors: Regulated gene expression" (2000)
Found on Publication Page
16
van Praag, H. and Kempermann, G. and Gage, F.H. "Neural consequences of enviromental enrichment" (2000)
Found on Publication Page
In 1999
15
Kafri, T. and Van Praag, H. and Ouyang, L. and Gage, F.H. and Verma, I.M. "A packaging cell line for lentivirus vectors" (1999)
Found on Publication Page
14
Van Praag, H. and Christie, B.R. and Sejnowski, T.J. and Gage, F.H. "Running enhances neurogenesis, learning, and long-term potentiation in mice" (1999)
Found on Publication Page
13
Van Praag, H. and Kempermann, G. and Gage, F.H. "Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus" (1999)
Found on Publication Page
In 1998
12
Van Praag, H. and Chun, D. and Black, I.B. and Sta ubli, U.V. "Unilateral hippocampal ablation at birth causes a reduction in contralateral LTP" (1998)
Found on Publication Page
11
Van Praag, H. and Qu, P.M. and Elliott, R.C. and Wu, H. and Dreyfus, C.F. and Black, I.B. "Unilateral hippocampal lesions in newborn and adult rats: Effects on spatial memory and BDNF gene expression" (1998)
Found on Publication Page
In 1997
10
Van Praag, H. and Black, I.B. and Sta ubli, U.V. "Neonatal vs. adult unilateral hippocampal lesions: Differential alterations in contralateral hippocampal theta rhythm" (1997)
Found on Publication Page
In 1996
9
Van Praag, H. and Alberch, J. and Perez-Navarro, E. and Wu, H. and Qu, P.M. and Black, I.B. and Dreyfus, C.F. "Unilateral neonatal hippocampal lesion alters septal innervation and trophism of the entorhinal cortex" (1996)
Found on Publication Page
In 1994
8
Van Praag, H. and Dreyfus, C.F. and Black, I.B. "Dissociation of motor hyperactivity and spatial memory deficits by selective hippocampal lesions in the neonatal rat" (1994)
Found on Publication Page
In 1993
7
Van Praag, H. and Falcon, M. and Guendelman, D. and Frenk, H. "The development of analgesic, pro- and anti-convulsant opiate effects in the rat" (1993)
Found on Publication Page
In 1992
6
van Praag, H. and Frenk, H. "The effects of systemic morphine on behavior and EEG in newborn rats" (1992)
Found on Publication Page
In 1991
4
van Praag, Henriette and Frenk, Hanan. "The development of stimulation-produced analgesia (SPA) in the rat" (1991)
Found on Publication Page
In 1990
3
van Praag, H. and Frenk, H. "The role of glutamate in opiate descending inhibition of nociceptive spinal reflexes" (1990)
Found on Publication Page
In 1989
2
Myslobodsky, M.S. and Bar-Ziv, J. and van Praag, H. and Glicksohn, J. "Bilateral alpha distribution and anatomic brain asymmetries" (1989)
Found on Publication Page
1
Myslobodsky, M.S. and Coppola, R. and Bar-Ziv, J. and Karson, C. and Daniel, D. and van Praag, H. and Weinberger, D.R. "EEG asymmetries may be affected by cranial and Brain parenchymal asymmetries" (1989)
Found on Publication Page