Research
Atp Synthase
Cancer
Medicinal Chemistry
Molecular Modeling, Molecular Model, Molecular Models
Neurodegenerative Diseases, Neurodegenerative Disease
Organic Chemistry
Anticancer Agents
Recent Developments, Recent Development
Adp Ribose
Multidrug Resistance
Natural Product, Natural Products
P Glycoprotein
Amino Acid, Amino Acids
Staphylococcus Aureus
Biological Evaluation
List of Publications (18)
In 2023
18
Dou X, Guo H, D'Amico T, Abdallah L, Subramanian C, Patel BA, Cohen M, Rubinstein JL, Blagg BSJ. "CryoEM Structure with ATP Synthase Enables Late-Stage Diversification of Cruentaren A." (2023)
Found on Publication Page
17
Byun JK, Lee SH, Moon EJ, Park MH, Jang H, Weitzel DH, Kim HH, Basnet N, Kwon DY, Lee CT, Stephenson TN, Jeong JH, Patel BA, Park SJ, Chi JT, Dewhirst MW, Hong J, Lee YM. "Manassantin A inhibits tumour growth under hypoxia through the activation of chaperone-mediated autophagy by modulating Hsp90 activity." (2023)
Found on Publication Page
In 2022
16
Dou X, Patel BA, D'Amico T, Subramanian C, Cousineau E, Yi Y, Cohen M, Blagg BSJ. "Synthesis and Evaluation of Simplified Cruentaren A Analogues." (2022)
Found on Publication Page
In 2021
15
Velagapudi UK, Patel BA, Shao X, Pathak SK, Ferraris DV, Talele TT. "Recent development in the discovery of PARP inhibitors as anticancer agents: a patent update (2016-2020)." (2021)
Found on Publication Page
In 2020
14
Patel BA, D'Amico TL, Blagg BSJ. "Natural products and other inhibitors of F(1)F(O) ATP synthase." (2020)
Found on Publication Page
In 2019
13
Velagapudi UK, Langelier MF, Delgado-Martin C, Diolaiti ME, Bakker S, Ashworth A, Patel BA, Shao X, Pascal JM, Talele TT. "Design and Synthesis of Poly(ADP-ribose) Polymerase Inhibitors: Impact of Adenosine Pocket-Binding Motif Appendage to the 3-Oxo-2,3-dihydrobenzofuran-7-carboxamide on Potency and Selectivity." (2019)
Found on Publication Page
In 2018
12
Patel BA, Abel B, Barbuti AM, Velagapudi UK, Chen ZS, Ambudkar SV, Talele TT. "Comprehensive Synthesis of Amino Acid-Derived Thiazole Peptidomimetic Analogues to Understand the Enigmatic Drug/Substrate-Binding Site of P-Glycoprotein." (2018)
Found on Publication Page
In 2017
11
Zhang H, Patel A, Wang YJ, Zhang YK, Kathawala RJ, Qiu LH, Patel BA, Huang LH, Shukla S, Yang DH, Ambudkar SV, Fu LW, Chen ZS. "The BTK Inhibitor Ibrutinib (PCI-32765) Overcomes Paclitaxel Resistance in ABCB1- and ABCC10-Overexpressing Cells and Tumors." (2017)
Found on Publication Page
10
Wang YJ, Patel BA, Anreddy N, Zhang YK, Zhang GN, Alqahtani S, Singh S, Shukla S, Kaddoumi A, Ambudkar SV, Talele TT, Chen ZS. "Thiazole-valine peptidomimetic (TTT-28) antagonizes multidrug resistance in vitro and in vivo by selectively inhibiting the efflux activity of ABCB1." (2017)
Found on Publication Page
In 2016
9
AbdelKhalek A, Ashby CR Jr, Patel BA, Talele TT, Seleem MN. "In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates." (2016)
Found on Publication Page
8
Zhang YK, Zhang GN, Wang YJ, Patel BA, Talele TT, Yang DH, Chen ZS. "Bafetinib (INNO-406) reverses multidrug resistance by inhibiting the efflux function of ABCB1 and ABCG2 transporters." (2016)
Found on Publication Page
In 2015
7
Werner MM, Patel BA, Talele TT, Ashby CR, Li Z, Zauhar RJ. "Dual inhibition of Staphylococcus aureus DNA gyrase and topoisomerase IV activity by phenylalanine-derived (Z)-5-arylmethylidene rhodanines." (2015)
Found on Publication Page
6
Zhang YK, Zhang H, Zhang GN, Wang YJ, Kathawala RJ, Si R, Patel BA, Xu J, Chen ZS. "Semi-synthetic ocotillol analogues as selective ABCB1-mediated drug resistance reversal agents." (2015)
Found on Publication Page
5
Cakir G, Kucukguzel I, Guhamazumder R, Tatar E, Manvar D, Basu A, Patel BA, Zia J, Talele TT, Kaushik-Basu N. "Novel 4-thiazolidinones as non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA polymerase." (2015)
Found on Publication Page
In 2014
4
Singh S, Prasad NR, Chufan EE, Patel BA, Wang YJ, Chen ZS, Ambudkar SV, Talele TT. "Design and synthesis of human ABCB1 (P-glycoprotein) inhibitors by peptide coupling of diverse chemical scaffolds on carboxyl and amino termini of (S)-valine-derived thiazole amino acid." (2014)
Found on Publication Page
3
Singh S, Prasad NR, Kapoor K, Chufan EE, Patel BA, Ambudkar SV, Talele TT. "Design, synthesis, and biological evaluation of (S)-valine thiazole-derived cyclic and noncyclic peptidomimetic oligomers as modulators of human P-glycoprotein (ABCB1)." (2014)
Found on Publication Page
In 2013
2
Patel BA, Ashby CR Jr, Hardej D, Talele TT. "The synthesis and SAR study of phenylalanine-derived (Z)-5-arylmethylidene rhodanines as anti-methicillin-resistant Staphylococcus aureus (MRSA) compounds." (2013)
Found on Publication Page
1
Patel BA, Krishnan R, Khadtare N, Gurukumar KR, Basu A, Arora P, Bhatt A, Patel MR, Dana D, Kumar S, Kaushik-Basu N, Talele TT. "Design and synthesis of L- and D-phenylalanine derived rhodanines with novel C5-arylidenes as inhibitors of HCV NS5B polymerase." (2013)
Found on Publication Page
